Sökning: "3D cell culture"

Visar resultat 1 - 5 av 12 uppsatser innehållade orden 3D cell culture.

  1. 1. Phenotype and function of imiquimod-treated MUTZ-3 derived Langerhans cells in potential psoriatic 3D skin model

    Master-uppsats, Malmö universitet/Institutionen för biomedicinsk vetenskap (BMV)

    Författare :Emilie Allentoft Schousboe; [2023]
    Nyckelord :3D models; imiquimod; Langerhans cells; MUTZ-3 cell line; pro-inflammatory cytokines; psoriasis;

    Sammanfattning : Upon encounter of an antigen, epidermis-resident Langerhans cells (LCs) become activated and present the processed antigen to T cells of the draining lymph nodes, resulting in tolerogenic or inflammatory responses. In psoriasis plaques, skin homeostasis is disrupted and replaced by an inflammatory dermatitis. LÄS MER

  3. 2. Development of Microfluidic 3D Cell Culture with a Nanocellulose-Based Scaffold for Spheroid Formation as a Potential Tool for Drug Screening

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Sara Payande; [2022]
    Nyckelord :3D cell culture; Scaffold; Microfluidics; Layer-by-Layer; Cellulose Nanofibrils; Spheroids; HepG2; 3D cellodling; Matris; Mikrofluidik; Layer-by-Layer; Cellulosa Nanofibriller; Sfäroider; HepG2;

    Sammanfattning : Abstract  Lack of clinical relevance is assumed to be the main reason behind the high failure rate of medical drugs in the very initial phases of clinical trials. Clinical relevance is difficult to achieve with current tools as they lack the biological and physiological cues found in vivo. LÄS MER

  4. 3. Hyaluronic Acid Hydrogel as a Scaffold for Cells’ Encapsulation

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för materialvetenskap

    Författare :Susanna Wärmegård; [2022]
    Nyckelord :hyaluronic acid; hydrogel; 3D cell culture;

    Sammanfattning : Hydrogels are high water-content polymers that mimic the extracellular matrix of cells. The polymers can have many sources and be of natural origin from the extracellular matrix (ECM) of cells or be synthetically derived. LÄS MER

  5. 4. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Kajsa Andreasson Dahlgren; [2021]
    Nyckelord :Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Sammanfattning : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. LÄS MER

  7. 5. 3D printing of alginates into tubular structures resembling human airways

    Master-uppsats, Lunds universitet/Avdelningen för Biomedicinsk teknik

    Författare :Tomasz Syski; [2021]
    Nyckelord :Tissue Engineering; Bioprinting; FRESH; Bioengineering; Alginate; Bioink; Biomaterial ink; Biomaterial; Airway; Regeneration; Hydrogel; 3D printing.; Technology and Engineering;

    Sammanfattning : Tissue shortage for lung transplantation remains a problem worldwide as lung transplantation is often the only available option with numerous possible complications. Generating lung tissue ex-vivo has been proposed as one way to potentially overcome this shortage. LÄS MER