Sökning: "Hepatocyte"

Visar resultat 1 - 5 av 7 uppsatser innehållade ordet Hepatocyte.

  1. 1. Characterization of hepatocyte derived metabolites of various New Psychoactive Substances using LC-QTOF-MS.

    Kandidat-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Sarah Ingvarsson; [2020]
    Nyckelord :4-fluoro-CUMYL-5-fluoro-PICA; synthetic cannabinoid; incubation; metabolites.;

    Sammanfattning : New psychoactive substances are becoming increasingly common in many parts of the world, and some of them are marketed as “legal highs” and are produced to circumvent the drug legislation, and they come in many unregulated forms. The aim of this research was to characterize the metabolites of a new psychoactive substance and hence provide the fundamental data needed for further research of toxicity and future drug testing. LÄS MER

  3. 2. Analysis of hydrogels for immobilisation of hepatocytes (HepG2) in 3D cell culturing systems

    Master-uppsats, Linköpings universitet/Teknisk biologi

    Författare :Elisabeth Westergren; [2018]
    Nyckelord :Hydrogel; Hepatocyte; Tuneable; PEG-peptide; 3D cell culture;

    Sammanfattning : In pharmaceutical development cell cultures are used as in vitro models to evaluate the function of drug candidates. In such research it is vital to have models that resemble the in vivo environment to get reliable results. LÄS MER

  4. 3. Assessment of new tracers targeting c-Met for therapeutic effects and possible radioimmunotherapy

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Författare :Caroline Lillkull; [2018]
    Nyckelord :;

    Sammanfattning : c-Met is a receptor tyrosine kinase that is activated by its ligand hepatocyte growth factor (HGF). c-Met is overexpressed or subject to abnormal activation through mutations or disrupted signaling pathways in various cancers, making it an attractive target for drug therapy with additional potential for imaging properties. LÄS MER

  5. 4. Development of a combined In-Cell ELISA and flow cytometry method for quantification of uptake of PEGylated nanoparticles by Raw264.7 and HepG2 cells

    Master-uppsats, Lunds universitet/Tillämpad biokemi

    Författare :Evelina Folkesson; [2016]
    Nyckelord :HepG2; Raw264.7; PEGylation; PEG; cancer; nanoparticles; In-Cell ELISA; flow cytometry; applied biochemistry; tillämpad biokemi; Technology and Engineering;

    Sammanfattning : Cancer is one of today’s most common causes of human mortality. For long, chemotherapeutics has been a conventional treatment of the disease, but due to its low precision and high frequency of side effects, this treatment has been highly debated. LÄS MER

  7. 5. Akut mikrocystinförgiftning hos däggdjur

    Kandidat-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Josefine Löfgren; [2013]
    Nyckelord :cyantotoxin; microcystin; absorption; distribution; metabolism; elimination; toxicitet; mekanismer; effekter;

    Sammanfattning : Förgiftningar hos däggdjur som druckit vatten kontaminerat med cyanotoxiner har observerats världen över, och riskerar att öka i takt med tilltagande övergödning och klimatförändringar. Denna litteraturstudie inriktar sig på mikrocystin (MC) som är det vanligaste och mest studerade cyanotoxinet. LÄS MER