Sökning: "PK PD"
Visar resultat 1 - 5 av 10 uppsatser innehållade orden PK PD.
1. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaciSammanfattning : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. LÄS MER
2. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control
Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Institutionen för reglerteknikSammanfattning : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). LÄS MER
3. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models
Master-uppsats, Uppsala universitet/Institutionen för farmaciSammanfattning : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. LÄS MER
4. Justering av farmakokinetiska parametrar i Hollow Fiber Experiment
Uppsats för yrkesexamina på grundnivå, Uppsala universitet/Institutionen för farmaciSammanfattning : 1. Sammanfattning Introduktion: Det finns idag flera allvarliga infektioner som har utmanande farmakologisk behandling, där tuberkulos är en av dem. Patogenerna som orsakar tuberkulos är svåra att behandla på grund av deras resistensmekanism, vilket gör att antibiotika inte fungerar lika effektivt längre som de gjorde tidigare. LÄS MER
5. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study
Kandidat-uppsats, KTH/Medicinteknik och hälsosystemSammanfattning : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. LÄS MER