Sökning: "Pharmacovigilance"

Visar resultat 1 - 5 av 12 uppsatser innehållade ordet Pharmacovigilance.

1. 1. Utilizing Transformers with Domain-Specific Pretraining and Active Learning to Enable Mining of Product Labels

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för beräkningsvetenskap

   Författare :Erik Norén; [2023]
   Nyckelord :Machine Learning; Natural Language Processing; NLP; BERT; Active Learning; AL; Pharmacovigilance; UMC; Uppsala Monitoring Centre; Structured Product Label; SPL; Transformers; Domain-Specific Pretraining; NER; Named Entity Recognition; Adverse Drug Reaction; ADR;

   Sammanfattning : Structured Product Labels (SPLs), the package inserts that accompany drugs governed by the Food and Drugs Administration (FDA), hold information about Adverse Drug Reactions (ADRs) that exists associated with drugs post-market. This information is valuable for actors working in the field of pharmacovigilance aiming to improve the safety of drugs. LÄS MER

3. 2. Named Entity Recognition for Case Narratives of Adverse Event Reports

   Master-uppsats, Uppsala universitet/Institutionen för informationsteknologi

   Författare :Jayant Yadav; [2023]
   Nyckelord :;

   Sammanfattning : In the field of pharmacovigilance (PV), signal detection and assessment activities play a crucial role. They require a PV assessor to read through countless adverse event reports which is manual labor-intensive work. To ease the reading process, visual highlighters can be provided by leveraging natural language processing techniques. LÄS MER

4. 3. Automated Application Security Testing in Two Pharmacovigilance Systems

   Master-uppsats, Uppsala universitet/Institutionen för informationsteknologi

   Författare :Daniel Fehrm; [2023]
   Nyckelord :;

   Sammanfattning : To improve the security of IT systems, companies can use automated security testing. In this thesis, three methods for automated security testingare evaluated and compared against each other. LÄS MER

5. 4. Free-text Informed Duplicate Detection of COVID-19 Vaccine Adverse Event Reports

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för systemteknik

   Författare :Erik Turesson; [2022]
   Nyckelord :Duplicate detection; Deduplication; Record linkage; Adverse Event Reports; COVID-19 Vaccines; Uppsala Monitoring Centre; VigiBase; Machine Learning; Gradient Boosted Decision Trees; BERT; Natural Language Processing; Pharmacovigilance; Individual Case Safety Reports;

   Sammanfattning : To increase medicine safety, researchers use adverse event reports to assess causal relationships between drugs and suspected adverse reactions. VigiBase, the world's largest database of such reports, collects data from numerous sources, introducing the risk of several records referring to the same case. LÄS MER

7. 5. Creation of a Next-Generation Standardized Drug Groupingfor QT Prolonging Reactions using Machine Learning Techniques

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för systemteknik

   Författare :Jacob Tiensuu; Elsa Rådahl; [2021]
   Nyckelord :Pharmacovigilance; Adverse Drug Reactions; MedDRA; VigiBase; WHODrug Global; QT prolongation; Torsades de Pointes; Individual Case Safety Reports; Text Recognition; Standardised Drug Grouping; Multinomial Logistic Regression; BERT;

   Sammanfattning : This project aims to support pharmacovigilance, the science and activities relating to drug-safety and prevention of adverse drug reactions (ADRs). We focus on a specific ADR called QT prolongation, a serious reaction affecting the heartbeat. Our main goal is to group medicinal ingredients that might cause QT prolongation. LÄS MER