Sökning: "SOD1"

Hittade 2 uppsatser innehållade ordet SOD1.

1. 1. CRISPR/Cas9 gene-editing in an in vitro model of a familial form of ALS

   Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

   Författare :Fredrik Nilsson; [2018]
   Nyckelord :ALS; SOD1; Amyotrophic lateral sclerosis; superoxide dismutase; CRISPR Cas9; sgRNA; stem cell; lentivirus; qPCR; FOXG1; nestin; immunocytochemistry; differentiation; forebrain neural progenitor; Applied Biochemistry; Biology and Life Sciences;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease characterized by the degeneration and death of both upper and lower motor neurons for which there is no cure currently available. The degeneration of motor neurons leads to the inability to carry out voluntary movement and death usually occurs 3-5 years after disease onset by respiratory failure. LÄS MER

3. 2. Why does trehalose not improve autophagy in the SOD1G93A transgenic mouse model of familial ALS?

   Uppsats för yrkesexamina på avancerad nivå, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

   Författare :Karolina Karlsson; [2015]
   Nyckelord :trehalose; SOD1; amyotrophic lateral sclerosis; ALS; autophagy; plaque; neurodegeneration; trehalos; SOD1; amyotrofisk lateralskleros; ALS; autofagi; plack; neurodegeneration;

   Sammanfattning : Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. LÄS MER