Sökning: "biopharmaceutical industry"

Visar resultat 1 - 5 av 16 uppsatser innehållade orden biopharmaceutical industry.

  1. 1. Influence of Peristaltic Pump Tubes on Protein Particles Formation for Lipase Enzyme Therapeutic Protein

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Salah Elden Omer; [2023]
    Nyckelord :Dynamic Image analysis; Protein aggregation; Peristaltic pump tubing; Particle characterization; PVC tubing; Silicone tubing; Surfactant; QICPIC; Pharmaceutical technology; Biology and Life Sciences;

    Sammanfattning : Introduction: In Bio-pharmaceutical production, peristaltic pump tubing is considered one of the factors that influence protein aggregation. Background: Protein particles present challenges for the control and analysis of various manufacturing processes in the biopharmaceutical industry for their significant effects on safety and quality. LÄS MER

  3. 2. Explainable Machine Learning for Lead Time Prediction : A Case Study on Explainability Methods and Benefits in the Pharmaceutical Industry

    Master-uppsats, KTH/Hållbar produktionsutveckling (ML)

    Författare :Paul Fussenegger; Niklas Lange; [2022]
    Nyckelord :Lead time; machine learning; explainability; regression analysis; production planning and control; Ledtid; maskininlärning; förklarbarhet; regressionsanalys; produktionsplanering och produktionsstyrning;

    Sammanfattning : Artificial Intelligence (AI) has proven to be highly suitable for a wide range of problems in manufacturing environments, including the prediction of lead times. Most of these solutions are based on ”black-box” algorithms, which hinder practitioners to understand the prediction process. LÄS MER

  4. 3. Quality and Regulatory Issues Related to Continuous Manufacturing of Biologics

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Sorosh Ziarati; [2022]
    Nyckelord :Continuous Manufacturing; Regulation; Continuous freeze drying; Biopharmaceutical; Trastuzumab; Pharmaceutical Technology; Technology and Engineering;

    Sammanfattning : Introduction: Continuous Manufacturing involves the continuous feeding of input materials into the transformation of in-process materials within, and the concomitant removal of output materials from a manufacturing process based on ICH guideline. In these systems, all the processes from raw material to final finished product would be continuously produced. LÄS MER

  5. 4. Physics-Informed Neural Networks for Liquid Chromatography

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för fysik

    Författare :Pontus Söderström; [2022]
    Nyckelord :;

    Sammanfattning : Liquid chromatography is a technique used to separate and purify components of a mixture. The method is frequently used in the biomedicine industry and life science to discover and develop new drugs. Here liquid chromatography can separate the drug candidate from its byproducts. LÄS MER

  7. 5. A high-throughput method for screening of protein binding behavior of multimodal anionic exchange ligands

    Master-uppsats, Uppsala universitet/Analytisk farmaceutisk kemi

    Författare :Ani Avedis; [2021]
    Nyckelord :Multimodal chromatography; multimodal anionic exchange ligands; product development; purification process; biological drugs; resins;

    Sammanfattning : The biopharmaceutical industry is constantly developing biological drugs, resulting in increased levels of product related impurities having similar characteristics as the target. The aim of the ligand project was to address future challenging purifications by developing new ligands for future resins for the biopharmaceutical industry. LÄS MER