Sökning: "enrichment optimization"

Visar resultat 1 - 5 av 11 uppsatser innehållade orden enrichment optimization.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  3. 2. Modellering, simulering och analys av kärnreaktorn BWRX-300

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Tillämpad kärnfysik

    Författare :Erik Backlund; [2023]
    Nyckelord :Kärnkraft; SMR; små modulära reaktorer; liten modulär reaktor; kärnreaktor; BWR; BWRX-300; självcirkulation; passiv säkerhet; GE Hitachi; cykellängd; härddesign; nukleär design; Simulate5; GNF2; kärnbränsle; reaktormodell;

    Sammanfattning : The demand for fossil-free energy production is rising due to electrification and increased consumption in the energy system. There are also multiple climate goals to reach, to preserve the possibilities of a sustainable future. LÄS MER

  4. 3. Training Machine Learning-based QSAR models with Conformal Prediction on Experimental Data from DNA-Encoded Chemical Libraries

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Gökçe Geylan; [2021]
    Nyckelord :Machine Learning; DNA-Encoded Chemical Library; Support Vector Machine; Random Forest; Conformal Prediction; QSAR;

    Sammanfattning : DNA-encoded chemical libraries (DEL) allows an exhaustive chemical space sampling with a large-scale data consisting of compounds produced through combinatorial synthesis. This novel technology was utilized in the early drug discovery stages for robust hit identification and lead optimization. LÄS MER

  5. 4. Moving Away from Proximal Ligation to Study Higher Order Chromatin Complexes at High Resolution

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Pontus Höjer; [2019]
    Nyckelord :;

    Sammanfattning : Genome organization is increasingly believed to influence and participate in gene regulation. Thestudy of the interactions that constitute this organization is increasingly performed using chromosomeconformation capture (3C) technologies. LÄS MER

  7. 5. Optimering av käftkross för Kankbergsmalm

    Uppsats för yrkesexamina på grundnivå, Luleå tekniska universitet/Institutionen för teknikvetenskap och matematik

    Författare :Markus Nilsson; [2018]
    Nyckelord :Käftkross; malmbrytning; optimering;

    Sammanfattning : Kankberg’s gold and tellurium ore has been shown to consist of more easily-ground ore and more hard-ground ore for the last decade. When the hard-ground ore enters the enrichment-plant so can the flow rate of the autogenous mill almost halved, from 110 ton/hour (easily-ground ore) compared to 60 ton/hour (hard-ground ore). LÄS MER