Sökning: "mass spectrometry based proteomics"

Visar resultat 1 - 5 av 14 uppsatser innehållade orden mass spectrometry based proteomics.

  1. 1. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Johan Thorsson; [2023]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. LÄS MER

  3. 2. Single-cell transcriptomic and antibody-based proteomic analysis of Sertoli cell-specific markers in human testis

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Katharina Stanzel; [2023]
    Nyckelord :;

    Sammanfattning : The testis is a complex organ responsible for sperm production and hormone synthesis. Spermatogenesis, the process of sperm formation, occurs in the seminiferous tubules and involves the coordinated development of germ cells with the support of Sertoli cells. LÄS MER

  4. 3. Optimal peptide quantification via machine learning enhanced fragment ion ranking in DIA-MS proteomics

    Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

    Författare :Lina Lu; [2022]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : In a standard mass spectrometry workflow, acquired mass spectra are searched against a library of peptides to extract peptide spectra matches (PSMs). Peptides are normally quantified by aggregating the intensities of fragment ions extracted from MS/MS spectra. LÄS MER

  5. 4. Combining output from MS-based proteomics search engines using spectrum predictors

    Master-uppsats, KTH/Proteinvetenskap

    Författare :William Hadd; [2022]
    Nyckelord :Mass spectrometry; Proteomics; machine learning; search engines; Masspektrometri; Proteomik; Maskininlärning; Transformers; Sökmotorer;

    Sammanfattning : Masspektrometri (MS) är en analysmetod som indikerar provers kemiska sammansättning. Provernas innehåll fragmenteras och joniseras, varefter jonernas förhållande mellan massa och laddning (m/z) och sammanlagda intensiteter mäts i form av ett masspektrum. LÄS MER

  7. 5. Theoretical Fundamentals of Computational Proteomics and Deep Learning- Based Identification of Chimeric Mass Spectrometry Data

    Master-uppsats, KTH/Skolan för elektroteknik och datavetenskap (EECS)

    Författare :Jens Settelmeier; [2021]
    Nyckelord :Computational proteomics; mass spectrometry; chimera identification; machine learning; deep learning; big data; bioinformatics; Beräkningsproteomik; masspektrometri; kimäridentifiering; maskininlärning; djupinlärning; stora data; bioinformatik;

    Sammanfattning : A complicating factor for peptide identification by MS/MS experiments is the presence of “chimeric” spectra where at least two precursor ions with similar retention time and mass co- elute in the mass spectrometer. This results in a spectrum that is a superposition of the spectra of the individual peptides. LÄS MER