Sökning: "mass spectrometry"

Visar resultat 1 - 5 av 310 uppsatser innehållade orden mass spectrometry.

  1. 1. Tracing Tempera through Time-of-Flight Secondary Ion Mass Spectrometry Analysing samples from four icons from the Nationalmuseum collection

    Master-uppsats, Göteborgs universitet/Institutionen för kulturvård

    Författare :Nina Olivier; [2024-01-30]
    Nyckelord :Icons; tempera; emulsions; analysis methods; ToF-SIMS;

    Sammanfattning : This thesis will analyze samples in form of cross-sections taken from four icons of the Nationalmuseum collection, two Russian, from the 18th and 19th centuries and two Greek, also from the 18th and 19th centuries, using the Time-of-Flight Secondary Ion Mass Technique. The objective is to detect, isolate and, if possible, identify the amino acids and the fatty acids in the protein and lipids used in the tempera, the ground, and the olifa using Time of Flight Secondary Ion Mass Spectrometry. LÄS MER

  2. 2. Synthesis of aromatic thiol ligands for the formation of thermoelectric materials

    Master-uppsats, KTH/Kemi

    Författare :Clément Bouchut; [2024]
    Nyckelord :ligand; organic chemistry; organic synthesis; thermoelectric materials; thiol; ligand; organisk kemi; organisk syntes; termoelektriska material; tiol;

    Sammanfattning : I detta arbete så har en uppsättning aromatiska ditiol-ligander framställts (3,5-dimerkaptobensoesyra I, methyl-3,5-dimerkaptobensoat II, 3,5-dimerkaptotoluen III, 4,6-dimerkaptoisoftalaldehyde IV). En trestegssyntes innehållande Newman-Kwart omlagring som nyckelsteg användes för framställning av föreningarna I-III medan förening IV togs fram via en annan syntesväg. LÄS MER

  3. 3. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  4. 4. Leveraging CNN for Automated Peak Picking in Untargeted Metabolomics without Parameter Dependencies

    Master-uppsats, Göteborgs universitet/Institutionen för data- och informationsteknik

    Författare :Vivian Wang; Lidia Yalew; [2023-10-19]
    Nyckelord :Deep learning; Convolutional neural network; LC-MS; Peak Detection; Metabolomics; Faster R-CNN;

    Sammanfattning : Metabolomics is a scientific discipline that involves the thorough analysis of small molecules, known as metabolites, found within a biological system. Furthermore, liquid chromatography-mass spectrometry (LC-MS) is a commonly used analytical technique in metabolomics for analysing biological samples due to its broad coverage of the measurable metabolome. LÄS MER

  5. 5. Creating a High-Throughput Workflow for Automated Peptide Characterization using LC-MS

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Sara Forsberg; [2023]
    Nyckelord :High-throughput analysis; Impurity profiling; UHPLC-HRMS; Peptide characterization; Peptide descriptors; Analytical chemistry; Technology and Engineering;

    Sammanfattning : In the early stage of a drug discovery project, there is a need for efficient methods that can analyse peptides in short time. This includes methods that confirm the peptide’s identity and estimates its relative purity in an efficient and reliable way. LÄS MER