Sökning: "molecular cell biology"

Visar resultat 1 - 5 av 52 uppsatser innehållade orden molecular cell biology.

  1. 1. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Samuel Eriksson Lidbrink; [2023]
    Nyckelord :AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Sammanfattning : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. LÄS MER

  3. 2. Let Us Put Our Brains in the Spotlight – Literally!

    Kandidat-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

    Författare :Elsa Karjalainen; [2023]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Neurons are the working force in each vertebrate’s nervous system. These small cells have the important task of transferring information in the form of electrical charges called action potentials. Neurons make it possible for us to sense touch, process our environment, and store memory. LÄS MER

  4. 3. Image-Based Classification Solutions for Robust Automated Molecular Biology Labs

    Master-uppsats, KTH/Medicinteknik och hälsosystem

    Författare :Arnold Teo; [2023]
    Nyckelord :Neural networks; Deep learning; Transfer learning; TensorFlow; Single-cell genomics; Image classification; Neurala nätverk; Djupinlärning; Överförd inlärning; TensorFlow; Enskild cellgenomik; Bildklassificering;

    Sammanfattning : Single-cell genomics (SCG) are methods for investigating heterogeneity between biological cells, among these is Smart-seq which sequences from RNA molecules. A more recent version of this method is Smart-seq3xpress which is currently in the process of being automated by the Sandberg lab at Karolinska Institutet. LÄS MER

  5. 4. Towards time-resolved cryo-EM of SARS-CoV-2 replication-transcription complex and Staphylococcus aureus DNA gyrase

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Anna Králová; [2023]
    Nyckelord :time-resolved cryo-EM; DNA gyrase; SARS-CoV-2; replication-transcription complex; protein purification;

    Sammanfattning : Time-resolved cryo-EM has already provided ground-breaking discoveries in various fields, including structural biology, biochemistry, and drug development. Compared to traditional structural biology methods where mostly stabilized conformations are reconstructed, the main advantage of time-resolved cryo-EM is its ability to capture dynamic processes in biological samples at near-atomic resolution, which allows for studying biological structures as they change and interact in real-time. LÄS MER

  7. 5. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Johan Thorsson; [2023]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. LÄS MER