Sökning: "18O-water"

Hittade 3 uppsatser innehållade ordet 18O-water.

  1. 1. Photodegradation study of 3,5-diamino-6-chloro- N-(2-(methylamino)ethyl)pyrazine-2-carboxamide using preparative SFC and LC-MS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Sara Sillén; [2016]
    Nyckelord :photodegradation; UPLC; SFC; liquid chromatography; supercritical fluid chromatography; mass spectrometry; freeze drying; 18O-water; analytical chemistry; structure elucidation; photodegradants;

    Sammanfattning : In this project the photodegradation of 3,5-diamino-6-chloro-N-(2-(methylamino)ethyl)pyrazine-2-carboxamide was studied. A hypothetical degradation pattern for the compound was proposed and the aim of the project was to study the formed secondary photodegradants and to, if possible, structure elucidate some of these compounds. LÄS MER

  3. 2. Evaluation of a UPLC-MS method using 18O-labelled water for the identification of hydrolytic degradants of drug substances

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för analytisk farmaceutisk kemi

    Författare :Viktor Kjellberg; [2015]
    Nyckelord :hydrolysis; degradation; degradants; 18O; 18O-water; liquid chromatography; mass spectrometry; analytical chemistry; structure eludication;

    Sammanfattning : In this master’s thesis the hydrolytic degradation in 18O-water solutions of six drug substances has been studied. The aim was to develop a mass spectrometric method for easier identification of degradants, since hydrolysis in 18O-water will generate degradants with higher mass compared with hydrolysis in regular water. LÄS MER

  4. 3. Development of a Niobium target for routine production of [18F]fluoride with a MC 16 Scanditronix cyclotron

    Master-uppsats, Lunds universitet/Sjukhusfysikerutbildningen

    Författare :Jonathan Siikanen; [2006]
    Nyckelord :Nukleärmedicin; Medicine and Health Sciences;

    Sammanfattning : The purpose with this work has been to develop and construct a Niobium target for the production of [18F]fluoride with a MC 16 Scanditronix cyclotron. The future demand larger amounts of [18F]fluoride and to satisfy the forthcoming needs an enhanced target needs to be installed on the cyclotron. LÄS MER