Sökning: "5xFAD"

Hittade 1 uppsats innehållade ordet 5xFAD.

  1. 1. Olfactory performance and neuropathology in the Tg6799 strain of Alzheimer’s disease model mice

    Master-uppsats, Institutionen för fysik, kemi och biologi

    Författare :Hanna Österman; [2010]
    Nyckelord :5xFAD; Alzheimer’s disease; amyloid precursor protein; amyloid β; cognitive impairment; olfactory deficit.;

    Sammanfattning : The present study evaluated olfactory and cognitive abilities of the Tg6799 (also called 5xFAD) strain of Alzheimer’s disease (AD) model mice of two different age groups (2-3 and 8-10 months of age), and one group of healthy control mice (9-10 months). Employment of an operant conditioning paradigm using an automated olfactometer, an olfactory habituation/dishabituation test and a spatial learning test with non olfactory cues resulted in data showing that the 5xFAD mice develop olfactory impairments already at 2-3 months of age. LÄS MER