Sökning: "6-mercaptourine"

Hittade 1 uppsats innehållade ordet 6-mercaptourine.

  1. 1. In vitro studies of Thiopurine S-Methyltransferase: Ligand binding interactions and development of a new enzymatic activity assay for TPMTwt, TPMT*6 and TPMT*8

    Kandidat-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi; Linköpings universitet/Tekniska fakulteten

    Författare :Lovisa Hemmingsson; Johan Klasén; [2015]
    Nyckelord :Thiopurine S-Methyltransferase; 6-mercaptourine; methotrexate; isothermal titration calorimetry; fluorescence spectroscopy;

    Sammanfattning : Acute lymphoblastic leukemia, one of the most malignant cancer forms in children is commonly treated with the thiopurine 6-mercaptopurine (6-MP) in combination with a high dose of methotrexate (MTX). 6-Mercaptopurine is in the body metabolized by the enzyme thiopurine S-methyltransferase (TPMT). LÄS MER