Sökning: "ACQUITY UPLC BEH C18"
Hittade 2 uppsatser innehållade orden ACQUITY UPLC BEH C18.
1. Development of separation method for analysis of oligonucleotides using LC-UV/MS
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk farmaceutisk kemiSammanfattning : Introduction Oligonucleotides are short nucleic acid chains, usually 19-27mer long. They bind to their corresponding chain, making a specific inhibition possible. In pharmaceuticals, this can be used to inhibit the expression of a gene or protein of interest. LÄS MER
2. Evaluation of a UPLC-MS method using 18O-labelled water for the identification of hydrolytic degradants of drug substances
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för analytisk farmaceutisk kemiSammanfattning : In this master’s thesis the hydrolytic degradation in 18O-water solutions of six drug substances has been studied. The aim was to develop a mass spectrometric method for easier identification of degradants, since hydrolysis in 18O-water will generate degradants with higher mass compared with hydrolysis in regular water. LÄS MER