Sökning: "AcclaimTM Mixed Mode WAX-1"

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  1. 1. Development of separation method for analysis of oligonucleotides using LC-UV/MS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk farmaceutisk kemi

    Författare :Björs Ida; [2018]
    Nyckelord :Oligonucleotides; UPLC; liquid chromatography; time of flight; mass spectrometry; reversed-phase weak anion exchange; AcclaimTM Mixed Mode WAX-1; DNAPacTM RP; ACQUITY UPLC BEH C18;

    Sammanfattning : Introduction Oligonucleotides are short nucleic acid chains, usually 19-27mer long. They bind to their corresponding chain, making a specific inhibition possible. In pharmaceuticals, this can be used to inhibit the expression of a gene or protein of interest. LÄS MER