Sökning: "Affibody® Molecule"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden Affibody® Molecule.

  1. 1. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

    Författare :Astrid Haraldsson; [2023]
    Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

    Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

  3. 2. Scale-down modelling of the upstream process for production of Affibody® Molecules

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Philip Masreliez; [2022]
    Nyckelord :Scale-down modelling; protein expression; Affibody® molecule; FeedPlate®; EnPresso® B; STR; Nedskalad produktionsmodell; proteinuttryck; Affibodymolekyler; FeedPlate®; EnPresso® B; STR;

    Sammanfattning : I detta projekt har uttrycket av Affibodymolekyler i bioreaktorer av olika volymetriska skalor jämförts för att fastställa om ett tillförlitligt samband mellan de olika bioreaktorernas prestanda kan etableras för att möjliggöra utvecklingen av en nedskalad produktionsmodell för Affibodymolekyler. Baslinjen för jämförelsen i denna studie har varit en enliters- stirred tank reactor (STR) som de andra (mindre) bioreaktorernas prestanda jämfördes med. LÄS MER

  4. 3. Hello P. pastoris! : The cultivatin and expression of proteins in the yeast Pichia pastoris

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Håkansson Anja; Dalén Therese; Gröblacher Josefine; Göransson William; Jaksties Jonathan; Ortstad Nathalie; Lenkeit Gesser Pauline; [2022]
    Nyckelord :Affibody AB; Pichia pastoris; pAOX1; pAOX2; pFLD1; pGAP; cultivation; fermentation; glycosylation;

    Sammanfattning : Producing pharmaceuticals in Escherichia coli inevitably comes with an extensive purification process. This is because many of the native proteins of E. coli are immunogenic to humans, especially the heat and pH resistant endotoxins located in the membrane of E. coli. LÄS MER

  5. 4. Development of an Affibody-based Prodrug Against HER2 for Cancer Therapy

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Cornelia Westerberg; [2021]
    Nyckelord :Affibody; therapeutic protein; prodrug; affibody-based prodrug; HER2-targeted therapy;

    Sammanfattning : Affinity proteins constitute an important category of cancer therapeutics. Owing to properties such as high target affinity and selectivity, therapeutic proteins offer more targeted therapy than small molecule drugs. The target molecules are typically proteins that are overexpressed on the surface of tumour cells, such as membrane-bound receptors. LÄS MER

  7. 5. Screening of Hydrophobic Interaction Chromatography for various Affibody® Molecules

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Sebastian Persson; [2020]
    Nyckelord :;

    Sammanfattning : Affibody® molecules are small affinity proteins with great opportunities in the application of biotechnological areas. Their popularity as biomolecules in pharmaceutical applications and research entails that the purity of Affibody® molecules is essential for their use as safe medical drugs. LÄS MER