Sökning: "Alternativ Splicing"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden Alternativ Splicing.

  1. 1. Differential expression and function of fubl-1 gene isoforms in C. elegans

    Kandidat-uppsats, Uppsala universitet/Molekylärbiologi; Uppsala universitet/Mikrobiologi och immunologi; Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Joel Pålsson; [2022]
    Nyckelord :isoform; gene expression; C elegans; protein; alternative splicing; isoformer; genuttryck; C elegans; protein; alternativ splicing;

    Sammanfattning : Alternative splicing is the process of producing a variety of transcripts from one and the same gene. This adds further possible variability to gene expression and can in theory mean that one protein coding gene can produce multiple proteins with potentially different functions. LÄS MER

  3. 2. Alternativ Splicing som biomarkör vid systemisk lupus erythematosus

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Lina Rehnman; [2022]
    Nyckelord :systemisk lupus erythematosus; SLE; alternativ splicing; transkription;

    Sammanfattning : Characteristics as unknown cause, complicated pathophysiology and a great amount of complexity are describing systemic lupus erythematosus (SLE) more than well. It’s an autoimmune disease that is almost exclusive for women in their reproductive years and are believed to correlate with both genetics and environmental factors. LÄS MER

  4. 3. Modeling the intronic regulation of Alternative Splicing using Deep Convolutional Neural Nets

    Master-uppsats, KTH/Skolan för datavetenskap och kommunikation (CSC)

    Författare :Johannes Linder; [2015]
    Nyckelord :Machine Learning; Deep Learning; CNN; CNNs; Convolutional Neural Networks; Convolutional Neural Nets; Neural Networks; Neural Nets; Synthetic Biology; Alternative Splicing; AS; Splicing; DNA Regulation; Synthetic DNA; Massively Parallel Library; Maskinlärning; CNN; CNNs; Convolutional Neural Networks; Convolutional Neural Nets; Faltning; Neurala Nätverk; Neurala Nät; Syntetisk Biologi; Alternativ Splicing; Splicing; AS; DNA; Massivt Parallellt Bibliotek; Syntetiskt DNA;

    Sammanfattning : This paper investigates the use of deep Convolutional Neural Networks for modeling the intronic regulation of Alternative Splicing on the basis of DNA sequence. By training the CNN on massively parallel synthetic DNA libraries of Alternative 5'-splicing and Alternatively Skipped exon events, the model is capable of predicting the relative abundance of alternatively spliced mRNA isoforms on held-out library data to a very high accuracy (R2 = 0. LÄS MER

  5. 4. Histonmodifieringar och alternativ splicing

    Kandidat-uppsats, Institutionen för fysik, kemi och biologi

    Författare :Jenny Berggren; [2011]
    Nyckelord :Alternative splicing; Histone modifications; exon; intron; pre-mRNA splicing; splicing regulation; chromatin- adaptor system; integrated model; Alternativ splicing; Histonmodifieringar; exon; intron; pre-mRNA splicing; splicing regulering; kromatin- adaptor system; integrerad modell;

    Sammanfattning : Alternativ splicing av pre-mRNA ger upphov till proteindiversitet. Histonmodifieringar kopplas till den alternativa splicingens reglering genom adaptorsystem som overfor den epigenetiska informationen direkt till splicingfaktorerna. LÄS MER

  7. 5. Felaktig alternativ splicing: Vissa mutationer i BRCA1, BRCA2, ERα och ERβ är starkt förknippade med bröstcancer

    Kandidat-uppsats, Institutionen för fysik, kemi och biologi

    Författare :Lisa Cederberg; [2011]
    Nyckelord :Alternative Splicing; BRCA1; BRCA2; Breast Cancer; ERα; ERβ; Alternativ splicing; BRCA1; BRCA2; Bröstcancer; ERα; ERβ;

    Sammanfattning : Alternative splicing is a process that partly rejects the common definition of a gene – that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. LÄS MER