Sökning: "Alternativ splicing"
Visar resultat 1 - 5 av 8 uppsatser innehållade orden Alternativ splicing.
1. Differential expression and function of fubl-1 gene isoforms in C. elegans
Kandidat-uppsats, Uppsala universitet/Molekylärbiologi; Uppsala universitet/Mikrobiologi och immunologi; Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Alternative splicing is the process of producing a variety of transcripts from one and the same gene. This adds further possible variability to gene expression and can in theory mean that one protein coding gene can produce multiple proteins with potentially different functions. LÄS MER
2. Alternativ Splicing som biomarkör vid systemisk lupus erythematosus
Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)Sammanfattning : Characteristics as unknown cause, complicated pathophysiology and a great amount of complexity are describing systemic lupus erythematosus (SLE) more than well. It’s an autoimmune disease that is almost exclusive for women in their reproductive years and are believed to correlate with both genetics and environmental factors. LÄS MER
3. Modeling the intronic regulation of Alternative Splicing using Deep Convolutional Neural Nets
Master-uppsats, KTH/Skolan för datavetenskap och kommunikation (CSC)Sammanfattning : This paper investigates the use of deep Convolutional Neural Networks for modeling the intronic regulation of Alternative Splicing on the basis of DNA sequence. By training the CNN on massively parallel synthetic DNA libraries of Alternative 5'-splicing and Alternatively Skipped exon events, the model is capable of predicting the relative abundance of alternatively spliced mRNA isoforms on held-out library data to a very high accuracy (R2 = 0. LÄS MER
4. Histonmodifieringar och alternativ splicing
Kandidat-uppsats, Institutionen för fysik, kemi och biologiSammanfattning : Alternativ splicing av pre-mRNA ger upphov till proteindiversitet. Histonmodifieringar kopplas till den alternativa splicingens reglering genom adaptorsystem som overfor den epigenetiska informationen direkt till splicingfaktorerna. LÄS MER
5. Felaktig alternativ splicing: Vissa mutationer i BRCA1, BRCA2, ERα och ERβ är starkt förknippade med bröstcancer
Kandidat-uppsats, Institutionen för fysik, kemi och biologiSammanfattning : Alternative splicing is a process that partly rejects the common definition of a gene – that one gene codes for one specific protein. By variable combination of coding regions (exons) and exclusion of non-coding regions (introns), formation of several different mRNA-transcripts, and consequently several different proteins, can derive from the same gene. LÄS MER