Sökning: "Amino acid mutation"

Visar resultat 1 - 5 av 13 uppsatser innehållade orden Amino acid mutation.

  1. 1. Acquired and lost structure-functions of non-enveloped and enveloped viruses

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Diogo Filipe; [2022]
    Nyckelord :;

    Sammanfattning : Viruses are biological entities that constantly affect the world around us and in many cases they can harm the health of humans and negatively impact food production, in agriculture andfisheries. The project concept is that, through the structural studies of viruses that infectsimple hosts, it is possible to point out structural features that are unique and conserved inviruses, that infect human, other animals, and crops, in the same phylogenetic lineage. LÄS MER

  3. 2. Genetisk typning av ekvint herpesvirus typ 1 (EHV-1) : en studie av svenska stammar

    Uppsats för yrkesexamina på avancerad nivå, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Johan Wilhelm Öhrmalm; [2022]
    Nyckelord :Ekvint herpesvirus 1; EHV-1; virusabort; PCR; sekvensering; fylogenetiskt träd;

    Sammanfattning : Ekvint herpesvirus typ 1 (EHV-1) är ett vanligt virus som infekterar hästar världen över. Viruset orsakar flera kliniska former av sjukdomen; feber, respiratorisk form, abort, neonatal död samt centralnervös form. I Sverige diagnosticeras omkring 10–30 utbrott per år på Statens veterinärmedicinska anstalt, SVA. LÄS MER

  4. 3. Investigation of possible improvements of the stability of bispecific ADAPT proteins

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Ella Eriksson; [2021]
    Nyckelord :Protein purification; Affinity chromatography; ABD-derived domain; ADAPT protein; simultan binding;

    Sammanfattning : The aim of the project was to identify positions and amino acids that contribute to improved structure and stability of bispecific ADAPT proteins. During the 20 weeks project period, different amino acid substitutions were analysed to evaluate the effect on the three-helical structure and stability of bispecific ADAPTs targeting human serum albumin (HSA) and tumor necrosis factor α (TNFα). LÄS MER

  5. 4. Characterization of co-infections and minor variants of BK polyomavirus in clinical sample by NGS

    Magister-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Safia Khatoon; [2020]
    Nyckelord :BK polyomavirus; Co-infection; Mutation; Kidney transplant; Next generation sequencing;

    Sammanfattning : BK polyomavirus (BKV) is associated with urinary apparatus pathogenesis in kidney transplant recipient. Immune suppression triggers BKV reactivation that potentially causes polyomavirus associated nephropathy (PVAN), a major post-transplant problem causes graft rejection. LÄS MER

  7. 5. Enzyme engineering of a haloacid dehalogenase-like phosphatase from Thermotoga neopolitana for optimization of substrate specificity

    Master-uppsats, Lunds universitet/Bioteknik (master)

    Författare :Samuel Sutiono; [2016]
    Nyckelord :Catalytic efficiency; Haloacid dehalogenase-like hydrolase; Enzyme engineering; Thermal stability; Inhibition; biotechnology; bioteknik; Technology and Engineering;

    Sammanfattning : Haloacid dehalogenase (HAD)-like hydrolases represent a vast superfamily characterised by their ability to form covalent enzyme-substrate intermediates facilitating the cleavage of C-Cl, C-P, or CO-P bonds. Within this work one member of this superfamily, HAD from Thermotoga neopolitana (HADTn) exhibiting a phosphatase (P-O bond cleavage) like activity was investigated in the context of altering the substrate specificity. LÄS MER