Sökning: "Anticancer drug development"
Hittade 5 uppsatser innehållade orden Anticancer drug development.
1. Expanding the application of a novel proteomics tool for drug target and mechanism identification
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemiSammanfattning : In drug discovery and development, characterization of the drug targets and mechanisms of action is an essential step. ProTargetMiner is a publicly available proteome signature library of anticancer molecules and its automated bioinformatics platform can be used for drug target and mechanism deconvolution. LÄS MER
2. ProTargetMiner one step further : Deep comparative proteomics of Dying vs. Surviving cancer cells treated with anticancer compounds
Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemiSammanfattning : Cancer is a leading cause of mortality worldwide, responsible for nearly one in six deaths. Thus, there is a need for a greater understanding of cancer for the development of novel therapeutics. This master thesis project aims to compare the proteome signatures between dying and surviving cancer cells treated with diverse anticancer drugs. LÄS MER
3. Dendritiska nanogeler som platform för läkemedelsleverans
Uppsats för yrkesexamina på avancerad nivå, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Sammanfattning : Utveckling av polymer baserade läkemedelsbärare i nanostorlek har blivit allt viktigare för att effektivisera behandling och diagnosering av olika sjukdomar, speciellt cancer. Flera läkemedel som används i kemoterapi har bristfälliga egenskaper som låg löslighet i vatten, oönskad nedbrytbara till dess inaktiva form, och distribution i stora volymer till oönskade organ p. LÄS MER
4. The screening for novel proteasome inhibitors as a treatment of cancer using IncuCyte FLR and fluorometric microculture cytotoxicity assay.
Kandidat-uppsats, Institutionen för medicinsk biokemi och mikrobiologiSammanfattning : The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation. LÄS MER
5. Do the new signal transduction modulators have activity in vitro in tumor cells from ovarian carcinoma and lymphoma?
Kandidat-uppsats, Institutionen för medicinsk biokemi och mikrobiologiSammanfattning : During the last decades, chemotherapy with cytotoxic drugs has played a significant role in cancer therapy. It’s important to develop new anticancer drugs, and drug sensitivity testing in vitro can be used to find the right diagnosis for the newly developed substances. LÄS MER