Sökning: "Aurora Kinase A"

Hittade 4 uppsatser innehållade orden Aurora Kinase A.

  1. 1. Phenotypic profiling and drug screening in Rhabdomyosarcoma cell lines

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Laura Martina Lang; [2022]
    Nyckelord :Rhabdomyosarcoma; Phenotypic profiling; Phenotypic drug screening;

    Sammanfattning : Rhabdomyosarcoma (RMS) is a type of soft tissue sarcoma that mainly occurs in children. RMS can be divided into two subtypes embryonal (ERMS) and alveolar (ARMS). The ARMS subtype can be especially aggressive when a balanced chromosomal translocation is present. LÄS MER

  3. 2. Optimizing the Production of Aurora Kinase A and Validation of Constructs with different Sequential Lengths

    Master-uppsats, Linköpings universitet/Kemi

    Författare :Linnea Pierre; [2022]
    Nyckelord :Protein; Protein chemistry; Aurora Kinase A; Aurora A; Cancer; Structural Biology; Cancer research;

    Sammanfattning : Aurora Kinase A is a kinase involved in multiple signaling pathways and interactions during mitosis, making it an essential kinase that deregulated causes cancer diseases in affected patients. Structural research shows mainly static snapshots of possible conformations of the partly disordered protein. LÄS MER

  4. 3. Role of Aurora kinase in Medulloblastoma development with correlation to MYCN activity

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Rashmi Chowath; [2015]
    Nyckelord :brain tumor; N-Myc; primary cilium; aurora kinase;

    Sammanfattning : Brain tumors are abnormal tissue masses found, either malignant or benign in nature. Medulloblastoma is a brain tumor subtype found to arise in the hind region of the brain, which is highly malignant and has poor long term prospects in general. LÄS MER

  5. 4. Regulation of Aurora A activity during checkpoint recovery

    Master-uppsats, Institutionen för biologisk grundutbildning

    Författare :Yan Zhou; [2012]
    Nyckelord :AurA activation; G2 checkpoint; checkpoint recovery; Time-lapse FRET microscopy;

    Sammanfattning : Cell division requires accurate DNA replication and cells develop checkpoint mechanisms toensure the correct passage of the genetic material. Cells arrest by a checkpoint when DNAdamage is found. After the checkpoint is silenced, the cell cycle can be resumed. LÄS MER