Sökning: "BCRP"

Visar resultat 1 - 5 av 11 uppsatser innehållade ordet BCRP.

  1. 1. In silico and in vitro determination of substrate specificity for Breast Cancer Resistance Protein (BCRP) transporter at the blood-brain barrier

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Fen Wang; [2021]
    Nyckelord :BCRP; substrate specificity; BBB; ATP-binding cassette ABC transporter; Drug transport;

    Sammanfattning : Background The Breast Cancer Resistance Protein (BCRP) drug transporter is important for drug disposition and plays a critical role in regulating drug entry into the brain. Its substrate spectrum overlaps with substrates of Multi Drug Resistance Protein 1 (MDR1, P-gp), which influences and complicates the interpretation of data on drug distribution into tissues (e. LÄS MER

  3. 2. Models for predicting efflux transport over the blood-brain barrier

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Marjaneh Janani; [2020]
    Nyckelord :efflux transport; brain; blood-brain-barrier; Verapamil; Risperidone; Prazosin;

    Sammanfattning : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. LÄS MER

  4. 3. Models for predicting efflux transport over the blood-brain barrier

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Marjaneh Janani; [2020]
    Nyckelord :Efflux; blood-brain-barrier; modeling; transporter;

    Sammanfattning : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. LÄS MER

  5. 4. Effekten av sulforafan på genuttrycket av breast cancer resistance protein i MCF-7 celler

    Uppsats för yrkesexamina på avancerad nivå, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Karolina Sjöberg; [2015]
    Nyckelord :sulforafan; breast cancer resistance protein; BCRP; nuclear factor E2-related factor-2; Nrf2; MCF-7; bröstcancerceller; mjölk; sulforaphane; breast cancer resistance protein; breast cancer cells; milk;

    Sammanfattning : Sulforafan är en isothiocyanat-förening som finns i stora mängder i olika kålväxter. Sulforafan har setts ha en kemopreventiv inverkan bland annat genom att inducera fas II-enzymer styrda av transkriptionsfaktorn nuclear factor E2-related factor-2 (Nrf2). LÄS MER

  7. 5. Toxicological effects of food additives azo dyes

    Master-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Cristina Gil; [2014]
    Nyckelord :endocrine disruptor; Human adrenocortical H295R ; cell line; azo dyes; MTT assay;

    Sammanfattning : BACKGROUND: Azo dyes are widely used in foods, pharmaceuticals and cosmetics. They have been tested in several screenings regarding their effects on human health, but very little data is available on endocrine disrupting effects. LÄS MER