Sökning: "Biodistribution"

Visar resultat 1 - 5 av 9 uppsatser innehållade ordet Biodistribution.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  3. 2. Feasibility of Dynamic SPECT-Renography with Automated Evaluation Using a Deep Neural Network

    Master-uppsats, Lunds universitet/Sjukhusfysikerutbildningen

    Författare :Viktor Rogowski; [2021]
    Nyckelord :Medicine and Health Sciences;

    Sammanfattning : Introduction: Renography is a standard diagnostic examination that evaluates renal function, renal pelvic dilatation and urinary obstruction. Renography is performed by injecting a radiopharmaceutical (predominately 99mTc-MAG3) and using gamma camera to image the biodistribution in a dynamic sequence. LÄS MER

  4. 3. Production and Evaluation of a Bombesin Analogue Conjugated to the Albumin-Binding Domain and DOTA for Prostate Cancer Radiotherapy

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Fredrika Landmark; [2021]
    Nyckelord :bombesin; prostate cancer; radiotherapy; human serum albumin; half-life extension; bombesin; prostatacancer; radioterapi; humant serumalbumin; halveringstidsförlängning;

    Sammanfattning : Prostate cancer is one of the most common types of cancer worldwide and claims hundreds of thousands of lives annually. Currently the most common treatment for prostate cancer is external beam radiotherapy, however, this treatment comes with serious side effects since it lacks selectivity for the cancer cells. LÄS MER

  5. 4. Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Jesper Borin; [2020]
    Nyckelord :ABD; ADAPT; HER2; CEACAM6; HSA; Phage display; Cancer therapy; Spatial bispecificity; Half-life extension; Biodistribution;

    Sammanfattning : Established biopharmaceuticals such as antibodies and derivatives thereof are relatively large. In cancer therapy, this creates a steep drug concentration gradient within tumors, leaving cells far from blood vessels effectively untreated. LÄS MER

  7. 5. Adsorption of lysozyme on Silica Surfaces and Specific ion effects

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Guillem Onyos de Plandolit Ruiz; [2019]
    Nyckelord :Ellipsometry; mesoporous silica nanoparticles; surfaces; physical chemistry; fysikalisk kemi; Chemistry;

    Sammanfattning : Biomedical application of nanoparticles is largely associated to their fate in biological media which, in fact, is related to their surface properties. Surface functionalitzation plays a key role in determining biodegradation, cytotoxicity and biodistribution through interactions which may be meditated by the macromolecules occurring in biological media. LÄS MER