Sökning: "Breast Stroma"

Hittade 5 uppsatser innehållade orden Breast Stroma.

  1. 1. Protokollutveckling för caldesmon samt en jämförelse med SMMS-1 av dess effektivitet som en myoepitelial markör på fibroadenom

    Kandidat-uppsats, Malmö högskola/Fakulteten för hälsa och samhälle (HS)

    Författare :Sahra Brentel; [2017]
    Nyckelord :Caldesmon; fibroadenom; immunohistokemi; protokoll; SMMS-1; tissue microarray;

    Sammanfattning : Immunohistokemi (IHK) är en metod som används för att undersöka närvaron av specifika biomarkörer i vävnad. Metoden utnyttjar antikroppars affinitet till antigen och dess närvaro visualiseras. Caldesmon är ett protein associerat med cytoskelettet som förekommer i glatta muskelceller och i icke-muskelceller. LÄS MER

  3. 2. Can the selective PDGF-receptor antagonist STI571 reduce hypoxia in solid tumors, and enhance drug uptake of Taxol, by lowering the interstitial fluid pressure in stroma rich breast carcinoma, BT-474

    Magister-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Marcus Runeson; [2015]
    Nyckelord :;

    Sammanfattning : Background Solid tumors have high interstitial fluid pressure, IFP. This cause a dramatic loss in uptake of anti cancer drugs with poor clinical outcome as result. Treatment with PDGF-receptor antagonist STI-571 lowers tumor IFP and enhances uptake of small compounds. LÄS MER

  4. 3. In situ molecular profilling of the microenvironment of breast carcinoma

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Mustapha Kaira; [2015]
    Nyckelord :Sequencing; gene expression analysis; cancer genetics; RCA; padlock probe;

    Sammanfattning : High stromal PDGF receptor B expression was shown to have strong prognostic value in a studyinvolving over 600 breast cancer patients however, the molecular role of the receptor in tumordevelopment remains unclear. In this project we studied the spatial distribution and expressionlevels of a panel genes and markers associated with PDGF signaling, in breast cancer tumormicroenvironment (TME) using a newly developed technique -in situ sequencing. LÄS MER

  5. 4. TGF-β (BETA) AND PERIOSTIN MODULATE EACH OTHER’S EXPRESSION IN BOTH BREAST STROMA AND TUMOR CELLS

    Magister-uppsats, Institutionen för vård och natur

    Författare :Anindita Das Burman; [2013]
    Nyckelord :TGF-β; Periostin; Breast Stroma; Breast Tumor; Tumor Microenvironment;

    Sammanfattning : Breast cancer is the most common cancer in female population worldwide. In addition to mutations, the breast tumor microenvironment especially the tumor cell - stroma interactions through extracellular matrix components and multiple growth factors have been shown to promote tumor progression. LÄS MER

  7. 5. Immunohistochemical detection of thymidine kinase 1 in canine mammary tumors and lymphomas

    Master-uppsats, SLU/Dept. of Clinical Sciences

    Författare :Alexandra Leijon; [2013]
    Nyckelord :mammary tumor; lymphoma; dog; cacine; thymidine kinase;

    Sammanfattning : The dog has often served as a model animal for humans in scientific studies. This is due to the fact that dogs are susceptible to a wide range of diseases which also affect humans. One example is cancer, a condition that affects dogs as well as owners. Neoplastic diseases account for 18-23 % of all deaths in dogs (Bonnet et al. LÄS MER