Sökning: "CHO-K1 cells"

Hittade 3 uppsatser innehållade orden CHO-K1 cells.

  1. 1. The roles of heparan sulfate in autophagy

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Asifa Khan; [2022]
    Nyckelord :Heparan sulfate; LC3-II; p62; Autophagy;

    Sammanfattning : Background: Autophagy is a lysosomal degradation process to eliminate damaged components from the cells. It also provides a survival mechanism in stressed conditions and limits growth processes. Heparan sulfate (HS) is a polysaccharide attached to different proteoglycans. LÄS MER

  3. 2. Development of a high-throughput platform for generation and early screening of high producing stable cell lines

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Jonathan Karlsson Persson; [2021]
    Nyckelord :CHO-K1; HEK293; CellCelector™; High-throughput screening; Protein A beads; Secondary antibody; CHO-K1; HEK293; CellCelector™; Högkapacitets-screening; Protein A-kulor; Sekundär antikropp;

    Sammanfattning : Produktionen av rekombinanta biofarmaceutiska läkemedel, exempelvis monoklonala antikroppar, är en oumbärlig men ansträngande process. Under 2019 var sju av de tio mest sålda läkemedlen globalt baserade på rekombinant producerade monoklonala antikroppar. LÄS MER

  4. 3. Evaluation of Potential Cytotoxic and Genotoxic Effects of Propolis in CHO-K1 Cells Using an in vitro Version of the Micronucleus Assay

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Elina Rosenborg; [2020]
    Nyckelord :propolis; micronucleus assay; genotoxicity; cytotoxicity; CHO-K1 cells; mitomycin C;

    Sammanfattning : Background Evaluating potential genotoxicity of pharmaceutical drug candidates is important during drug development. A method that can be used for this purpose is the micronucleus assay (MN- assay) which can identify agents that induce chromosomal damage. LÄS MER