Sökning: "CRBN"

Hittade 2 uppsatser innehållade ordet CRBN.

1. 1. Inverse Atmospheric Dispersion Modeling in Complex Geometries

   Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för fysik

   Författare :Charlie Pelland; [2022]
   Nyckelord :atmospheric dispersion modeling; dispersion modeling; invers dispersion modeling; atmospheric dispersion; invers atmospheric dispersion; CFD; computational fluid dynamics; radioactive release; openfoam; CRBN; dry deposition; dry deposition velocity; scavenging effect; wet deposition; optimization model; Reynolds Averaged Navier-Stokes; adjoint mode; time-dependent rain simulation; time-dependent rain; time dependent rain simulation; time dependent rain;

   Sammanfattning : In the event of a radioactive release in an urban environment the consequent response mustbe swift and precise. As soon as first responders have correct information, they can make anaccurate risk assessment. However, if the position, release rate and time of the radioactiverelease is unknown it is hard to know how the pollutant will spread. LÄS MER

3. 2. Chemical design, synthesis and biological evaluation of novel proteolysis targeting chimeras (PROTACs) for the degradation of NUDT5

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Preparativ läkemedelskemi

   Författare :Gabriel Tidestav; [2020]
   Nyckelord :protac; proteolysis targeting chimera; targetted protein degradation; nudt5; breast cancer; e3 ligase; ligands; vhl; crbn; theophylline;

   Sammanfattning : Proteolysis targeting chimeras (PROTACs) represent a new modality in drug design. They are bifunctional molecules; with one end, they bind to a protein of interest, and with the other end, they bind to endogenous E3 ligases. LÄS MER