Sökning: "Cardiomyocytes"

Visar resultat 1 - 5 av 14 uppsatser innehållade ordet Cardiomyocytes.

  1. 1. Developing Automated Cell Segmentation Models Intended for MERFISH Analysis of the Cardiac Tissue by Deploying Supervised Machine Learning Algorithms

    Master-uppsats, KTH/Kemi

    Författare :Julia Rune; [2023]
    Nyckelord :Cell Segmentation; Cellpose; Supervised Machine Learning; MERFISH; Heart Failure; Cellsegmentering; Cellpose; Övervakad Maskininlärning; MERFISH; Hjärtsvikt;

    Sammanfattning : Följande studie behandlar utvecklandet av automatiserade cellsegmenteringsmodeller med avsikt att identifiera gränser mellan celler i hjärtvävnad. Syftet är att möjliggöra analys av data genererad från multiplexed error-robust in situ hybridization (MERFISH). LÄS MER

  3. 2. Explorative bioinformatic analysis of cardiomyocytes in 2D &3D in vitro culture system

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Sruthy Janardanan; [2021]
    Nyckelord :Cardiomyocytes; Pluripotent stem cells; 2D; 3D; differentially expressed genes; Hub nodes; Hub-Bottleneck nodes;

    Sammanfattning : The in vitro cell culture models of human pluripotent stem cells (hPSC)-derived cardiomyocytes (CMs) have gained a predominant value in the field of drug discovery and is considered an attractive tool for cardiovascular disease modellings. However, despite several reports of different protocols for the hPSC-differentiation into CMs, the development of an efficient, controlled and reproducible 3D differentiation remains challenging. LÄS MER

  4. 3. Transcriptional changes in stem cell-derived cardiomyocytes during extended cell cultures

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Michel Jonathan Speh; [2020]
    Nyckelord :;

    Sammanfattning : The recent advancement in the field of stem cell research gave rise to high expectations from both general and scientific audiences, and indeed, stem cells and stem cell-derived cells have an enormous potential to forward the fields of medical research and regenerative medicine. Nevertheless, there are still many obstacles and limitations associated with stem cell technology. LÄS MER

  5. 4. Cardiac hypertrophy in human stem cells-derived cardiomyocytes : Biomarker identification and pathway analysis of endotheline-1 induced cardiac hypertrophy in human induced pluripotent stem cells-derived cardiomyocytes

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Benyapa Tangruksa; [2020]
    Nyckelord :;

    Sammanfattning : Cardiac hypertrophy is when heart muscles thicken as an adaptive response to several stimuli. Prolonged pathological cardiac hypertrophy can lead to heart failure and severe cardiovascular diseases. Scientists have faced challenges in studying cardiac hypertrophy due to the lack of human cardiomyocytes available. LÄS MER

  7. 5. Exercise-induced cardiac remodeling : a potential cause of pathological changes in the equine heart?

    Kandidat-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Maria Neil; [2019]
    Nyckelord :Cardiac remodeling; equine; horse; exercise; hypoxia; valvular regurgitation; cardiac murmur; atrial fibrillation;

    Sammanfattning : Cardiac remodeling is a response to exercise that has been reported in a number of different species. Intensified training will lead to an increasing demand on the cardiovascular capacity, because of the requirements of enhanced oxygen delivery, metabolism and thermoregulation. LÄS MER