Sökning: "Caspase-1"

Hittade 4 uppsatser innehållade ordet Caspase-1.

  1. 1. Upregulation of CLIC1 gene in THP1 cells stimulated by lipopolysaccharides

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Karldiony Roskvist; [2021]
    Nyckelord :;

    Sammanfattning : The NLRP3 inflammasome is a multiprotein complex that controls caspase-1 activation and the development of the pro-inflammatory cytokines IL-1 and IL-18, as well as pyroptosis. The NLRP3 inflammasome in murine macrophages is normally triggered by pathogen-associated molecular patterns as well as a variety of structurally unrelated stimuli. LÄS MER

  3. 2. Protein-protein interactions with and within the NLRP3 inflammasome : Evidence from STRING and literature studies

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Ralph Monte; [2020]
    Nyckelord :;

    Sammanfattning : Inflammasomes are multiprotein complexes that play a role in the innate immune system. One inflammasome is the NLRP3 inflammasome, which can be activated and primed by different stimuli that bind to pattern recognition receptors (PRRs). LÄS MER

  4. 3. Inflammasome : Investigating the effect of NEK7 in the activation of the NLRP3 Inflammasome

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Cosmas Adindu Uzowuru; [2020]
    Nyckelord :NLRP3 inflammasome; NEK7 protein; THP-1; Prime; activate; differentiate; stimulate; cytokines; Interleukin-1 Beta; Interleukin-18;

    Sammanfattning : Inflammation is a biological defence mechanism applied by living organisms against foreign invaders. In the response to DAMPs and PAMPs, organisms use inflammatory multi-protein complexes to fight the attackers. The most studied inflammasome proteins are NLRP3, ASC and Caspase-1. LÄS MER

  5. 4. Characterization of Macrophage Activation Induced by Leukotoxin from Aggregatibacter actinomycetemcomitans 

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för odontologi

    Författare :Niklas Sundling; Lisa Lü; [2018]
    Nyckelord :;

    Sammanfattning : ABSTRACT  Aggregatibacter actinomycetemcomitans (Aa), is a gram-negative, facultative anaerobe, non-motile coccobacilli colonizing the human oral cavity and is strongly associated with localized aggressive periodontitis (LAP). Aa possesses several virulence mechanisms, among others; Lipopolysaccharide (LPS), an endotoxin found in the outer membrane of Aa and Leukotoxin (LtxA), an exotoxin attached to the bacterial cell surface or in outer membrane vesicles and which has been correlating with periodontal disease mostly. LÄS MER