Sökning: "DNA methylation"

Visar resultat 1 - 5 av 34 uppsatser innehållade orden DNA methylation.

  1. 1. Impact of BPA, BPF and Mixture N1 on DNA-Methylation of GRIN2B and NR3C1 during human neuroprogenitor cell differentiation

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Fysiologi och miljötoxikologi

    Författare :Franziska Sophie Richter; [2023]
    Nyckelord :Epigenetics; Endocrine disrupting chemicals; DNA methylation; EDCs; Mixture effects; BPA; BPF; Mixture N1;

    Sammanfattning : Endocrine disrupting chemicals (EDCs) are ubiquitous and their adverse impact on nature, wildlife and humans is extensively researched. We are constantly exposed to EDCs, such as the widespread and extensively researched Bisphenol A, as well as its substitute Bisphenol F, which is coming into wider use, even though it is much less is researched and limited information is available about its endocrine effects. LÄS MER

  3. 2. Analys av DNA-metylering i genen CREBBP och dess koppling till autism

    Kandidat-uppsats, KTH/Medicinteknik och hälsosystem

    Författare :Karolina Söderberg; Sofie Fröjdman; [2023]
    Nyckelord :Methylation; autism; Matlab; DNA; CREBBP; DNA-sequencing; Metylering; autism; Matlab; DNA; CREBBP; DNA-sekvensering;

    Sammanfattning : Autism är en neuropsykiatrisk funktionsnedsättning som i olika utsträckning påverkar individens sätt att tänka, vara och kommunicera. Arv har visat sig vara en betydande faktor till varför vissa får autism, och forskning tyder på att det finns ett samband mellan autism och en obalans i metyleringsmönstret i vissa gener. LÄS MER

  4. 3. Identification of epigenetic biomarkers associated with the development of diabetic kidney disease in individuals with type 2 diabetes: a nested cohort study

    Master-uppsats, Lunds universitet/Socialmedicin och global hälsa

    Författare :Marian Paiva Marchiori; [2023]
    Nyckelord :Medicine and Health Sciences;

    Sammanfattning : Introduction. Type 2 diabetes (T2D) is the most common type of diabetes, and it can cause complications such as diabetic kidney disease (DKD), the main cause of end-stage renal disease worldwide. There is an urgent need to develop new biomarkers that would improve DKD’s risk prediction in patients with T2D. LÄS MER

  5. 4. Evaluation and implementation of quality control parameters for genome-wide DNA methylome sequencing

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Sara Ekberg; [2022]
    Nyckelord :;

    Sammanfattning : Epigenomics is the study of modifications to the genetic material without changes to the DNA sequence, one such modification is methylation of nucleotides. DNA methylation is associated with gene regulation and is studied in a variety of fields such as cancer and ageing. LÄS MER

  7. 5. Analysis of DNA methylation changes and behavioural outcomes in adulthood induced by prenatal exposure to a mixture of endocrine disrupting chemicals

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Shane Kamil; [2022]
    Nyckelord :Toxicology; Developmental biology; Epigenetics; Genetics; Methylation; EDC; Toxins; Chemicals; Mixture effect; Mediation; Toxikologi; Utvecklingsbiologi; Epigenetik; Genetik; Metylering; Miljögifter;

    Sammanfattning : Endocrine disrupting chemicals, or EDCs, are some of the most prevalent toxic chemicals found in the environment because of human activity and they have a variety of adverse effects on both humans and wildlife. A proposed mechanism through which EDCs can negatively affect an organism is via an epigenetic mechanism known as DNA methylation, which can affect the development of the organism with negative outcomes later in life. LÄS MER