Sökning: "Drug metabolism"

Visar resultat 1 - 5 av 46 uppsatser innehållade orden Drug metabolism.

  1. 1. The Quantitative Expression of Transport Proteins SLC38A1-11 in Nerve Cell Development

    Uppsats för yrkesexamina på grundnivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Maryam Dinar; [2023]
    Nyckelord :SLC38A1; SNAT1; SLC38A2; SNAT2; SLC38A3; SNAT3; SLC38A4; SNAT4; SLC38A5; SNAT5; SLC38A6; SNAT6; SLC38A7; SNAT7; SLC38A8; SNAT8; SLC38A9; SNAT9; SLC38A10; SNAT10; SLC38A11; SNAT11; SLC; SLC38; SNATs; SNAT; RT-qPCR; GABA; glutamine; glutamate;

    Sammanfattning : Solute carriers consist of over 400 genes and 66 subfamilies and are the largest group of membrane bound transporters. They facilitate movement of many molecules through cells and organelles and are crucial for upholding many key functions in the human body. They are also involved in the pathophysiology of several diseases. LÄS MER

  3. 2. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Johan Thorsson; [2023]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. LÄS MER

  4. 3. Structural and Functional Characterisation of the Human Mitochondrial Pyruvate Carrier

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Simon Gripvall; [2023]
    Nyckelord :biochemistry; complex; MPC; proteoliposomes; pyruvate; transport; Chemistry;

    Sammanfattning : The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases. LÄS MER

  5. 4. Påverkar graden av insulindysreglering effekten av behandling med kanagliflozin hos hästar med ekvint metabolt syndrom?

    Master-uppsats, SLU/Dept. of Clinical Sciences

    Författare :Ida Ivarsson; [2023]
    Nyckelord :Ekvint metabolt syndrom EMS ; Insulindysreglering ID ; Hyperinsulinemi; Kanagliflozin;

    Sammanfattning : Ekvint metabolt syndrom (EMS) kan förklaras som ett antal riskfaktorer som bidrar till utvecklingen av fång hos hästar. Insulindysreglering (ID) och obesitas med eller utan regional fettansättning utgör viktiga riskfaktorer som ingår i syndromet. Hästar med ID får onormalt höga insulinkoncentrationer i plasma, kallat hyperinsulinemi. LÄS MER

  7. 5. Toxicological analysis of Pyraclostrobin and Cyprodinilon Zebrafish larvae

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Kim Yeju; [2022]
    Nyckelord :gene expression; mixture effect; toxicity; pesticides; stress response;

    Sammanfattning : Cyprodinil and pyraclostrobin are widely used pesticides to protect many plants from attack of microorganisms and fungal diseases. Although cyprodinil and pyraclostrobin exist in the aquatic environment at low concentration, their leftovers in the ecosystems lead to oxidative damage and interfere development in aquatic animals at environmental-relevant concentration. LÄS MER