Sökning: "ERK"

Visar resultat 1 - 5 av 20 uppsatser innehållade ordet ERK.

  1. 1. Ligand-stimulated cleavage of PDGFR-beta

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Agni Karolina Tsiatsiou; [2023]
    Nyckelord :;

    Sammanfattning : Platelet-derived growth factor receptors (α and β) are included in the family of receptor tyrosine kinases (RTKs). The dimeric PDGF ligands bind to the PDGF receptors and this results in receptor dimerization, autophosphorylation, and thus activation. The autophosphorylated receptor dimer activates numerous signaling pathways. LÄS MER

  3. 2. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Kajsa Andreasson Dahlgren; [2021]
    Nyckelord :Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Sammanfattning : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. LÄS MER

  4. 3. The effects of NOX2 and NOX4 inhibitors on panc-1 cell viability

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för hälsovetenskaper

    Författare :Karl-Hermann Sielinou Kamgang; [2020]
    Nyckelord :;

    Sammanfattning : Pancreatic cancer is a leading cause of cancer related deaths worldwide and has a low survival rate 1 year after diagnosis. It is therfore important to identify new biomarkers and treatments to improve disease outcome. This experiment investigated the effects of different NOX2 and NOX4 inhibitors on Panc-1 cell lines. LÄS MER

  5. 4. Das Bildzitat Eine Untersuchung von Paul Klees Die Revolution des Viaduktes in drei Texten der deutschprachigen Prosa

    Uppsats för yrkesexamina på grundnivå, Högskolan Dalarna/Tyska

    Författare :Petra Frank; [2016]
    Nyckelord :Intermedialität Bildzitat Text-Bild-Verhältnis intermediality Paul Klee;

    Sammanfattning : Ziel dieser Arbeit ist die Untersuchung des Bildzitates und seiner Form. Ausgangspunkt ist ein Kunstwerk, Paul Klees Revolution der Viadukte, und dessen Versprachlichung, dem sognannten Bildzitat, in drei Texten der deutschen Prosa. LÄS MER

  7. 5. Characterization of pERK expression in amygdala and its role in nociceptive behavior

    Kandidat-uppsats, SLU/Dept. of Microbiology

    Författare :Mychelly Moraes De Siqueira; [2016]
    Nyckelord :amygdala; extracellular signal-regulated kinase ERK ; mitogen-activated protein kinase MAPK ; nociceptive; pain;

    Sammanfattning : Extracellular signal-regulated kinase (ERK), is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases. Functioning as intracellular signaling molecules, they are responsible for multiple extracellular signals transduction into diverse intracellular responses through transcriptional and post-translational regulations. LÄS MER