Sökning: "Elisabeth Jirström"

Hittade 1 uppsats innehållade orden Elisabeth Jirström.

  1. 1. Towards Identifying Pharmacodynamic Blood Biomarkers of MAP3K12 Inhibition

    Master-uppsats, Lunds universitet/Tillämpad biokemi

    Författare :Elisabeth Jirström; [2017]
    Nyckelord :Mitogen-activated protein kinase kinase kinase; MAP3K12; Amyotrophic lateral sclerosis; DLK; ALS; Pharmacodynamic; Biomarker; applied biochemistry; tillämpad biokemi; Technology and Engineering; Biology and Life Sciences; Medicine and Health Sciences; Chemistry;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons in the brain and spinal cord, for which there is no cure. Activation of the stress-induced c-Jun N-terminal kinase (JNK) signaling pathway, a critical mediator of neuronal apoptosis and axon degeneration, is evident in ALS and is therefore considered a potential target to prevent neurodegeneration. LÄS MER