Sökning: "Endoplasmic reticulum"

Visar resultat 1 - 5 av 13 uppsatser innehållade orden Endoplasmic reticulum.

  1. 1. Effects of phosphorylation on the ADP-ribosylation activity of PARP16

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Virginia Martín Cristóbal; [2023]
    Nyckelord :ADP-ribosylation; Kinases; PARP16; Phosphorylation; UPR biochemistry; Biochemistry; Chemistry;

    Sammanfattning : PARP16/ARTD15 is an intracellular mono-ADP-ribosyltransferase that catalyzes auto- and heteromodification by transfer of a single ADP-ribose moiety. It belongs to the ADP-ribosyltransferase (ART) superfamily. LÄS MER

  3. 2. The Role of Endoplasmic Reticulum Stress and Hepatic Stellate Cells in Inducing Chemoresistance in Hepatocellular Carcinoma

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk cellbiologi

    Författare :Jaafar Khaled; [2021]
    Nyckelord :Hepatocellular carcinoma; ER-stress; hepatic stellate cells; chemoresistance; doxorubicin; 4μ8C; Hepatocellulärt karcinom; ER-stress; hepatiska stellatceller; kemoresistens; doxorubicin; 4μ8C;

    Sammanfattning : Hepatocellular carcinoma (HCC) is the most common liver malignancy that usually develops in patients suffering from chronic liver diseases. One of the major problems faced in the treatment of HCC is severe chemoresistance. LÄS MER

  4. 3. Expression of the chloride channel CLCC1 is downregulated after 24 hours in LPS-primed THP-1 monocyte-like cell line

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Omar Babena; [2021]
    Nyckelord :;

    Sammanfattning : Inflammation is the body's response to infection or injury and is mediated by the innate immune system. The NLRP3 inflammasome is a multi-protein complex that is a major contributor to many inflammatory disorders. Emerging evidence suggests the involvement of the Endoplasmic reticulum stress with the NLRP3 inflammasome. LÄS MER

  5. 4. Activation of Placenta XBP-1 Signaling in Obese Women

    Kandidat-uppsats,

    Författare :Nabaa Ibraheem; [2021]
    Nyckelord :Western blot; placenta; fetma; graviditet; Multiplex qPCR; XBP-1 protein;

    Sammanfattning : Overweight (BMI 25–29) or obese (BMI over 30) pregnant women have an increased risk of complications during pregnancy and childbirth that can harm both women and their children.Due to increased risk for several complications such as of giving birth to large children, malformations or still births, the children have higher risk of obesity, blood pressure diseases and diabetes in childhood and later in life compared with children of normal weight. LÄS MER

  7. 5. Optimizing signal peptides for expression of recombinant antibodies in HEK293 cells

    Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Gustav Myhrinder; [2020]
    Nyckelord :Signal peptide; antibody; mammalian cell; HEK293; secretory pathway;

    Sammanfattning : Monoclonal antibodies are well-established as a therapeutic in the biopharmaceutical market, targeting a variety of diseases and with 79 approved products by the United States Food and Drug Administration in December 2019. Therapeutic monoclonal antibodies are commonly produced as recombinant proteins in mammalian cell lines, due to their capacity of post-translational modifications, most notably glycosylation. LÄS MER