Sökning: "Epigenetics"
Visar resultat 1 - 5 av 29 uppsatser innehållade ordet Epigenetics.
1. Impact of BPA, BPF and Mixture N1 on DNA-Methylation of GRIN2B and NR3C1 during human neuroprogenitor cell differentiation
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Fysiologi och miljötoxikologiSammanfattning : Endocrine disrupting chemicals (EDCs) are ubiquitous and their adverse impact on nature, wildlife and humans is extensively researched. We are constantly exposed to EDCs, such as the widespread and extensively researched Bisphenol A, as well as its substitute Bisphenol F, which is coming into wider use, even though it is much less is researched and limited information is available about its endocrine effects. LÄS MER
2. Analysis of DNA methylation changes and behavioural outcomes in adulthood induced by prenatal exposure to a mixture of endocrine disrupting chemicals
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Endocrine disrupting chemicals, or EDCs, are some of the most prevalent toxic chemicals found in the environment because of human activity and they have a variety of adverse effects on both humans and wildlife. A proposed mechanism through which EDCs can negatively affect an organism is via an epigenetic mechanism known as DNA methylation, which can affect the development of the organism with negative outcomes later in life. LÄS MER
3. Countergradient variation and compensatory growth in Moor frog (Rana arvalis) along a replicated latitudinal gradient
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : For evolution to occur over time, it is necessary for animals and plants to show phenotypic variation. If the individuals within populations of a species do not show observable differences among themselves, there will be a lack of driving force for natural selection to act on and decide which characteristic gets inherited from one generation to the next. LÄS MER
4. Cancer Driver Gene Detection using Deep Convolutional Neural Networks on H3K4me3 Enrichment Profiles
Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisationSammanfattning : In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. LÄS MER
5. Analysis of epigenetic changes induced by exposure to a mixture of endocrine disrupting chemicals in the mouse brain and a hippocampus mouse cell model
Master-uppsats, Uppsala universitet/Miljötoxikologi; Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Prenatal exposure to mixture N1, a chemical mixture consisting of four phthalate diesters,three pesticides and Bisphenol A, has been associated with behavioural changes as well as changes in gene expression in mice. In this study it was investigated whether the changes in gene expression could be explained by changes in DNA methylation. LÄS MER
