Sökning: "Freeze-drying"

Visar resultat 1 - 5 av 23 uppsatser innehållade ordet Freeze-drying.

  1. 1. Determination of Mass- and Heat Transfer Coefficients for Computer Modelling of Pharmaceutical Freeze-Drying

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Linnea Gustafsson; [2021]
    Nyckelord :Freeze-drying; Mass- and Heat Transfer; Pharmaceutical production; Simulation; MATLAB; Pharmaceutical technology; Technology and Engineering;

    Sammanfattning : This thesis work deals with the determination of mass- and heat transfer coefficients for pharmaceutical vial freeze-drying and the one-dimensional steady state computer modelling of primary drying. The overall heat transfer coefficient K_V for the vial/freeze-dryer system was successfully determined using a gravimetric method. LÄS MER

  2. 2. A Molecular Dynamics Simulation Study of the Protein Stability of Reteplase in Formulation with Various Excipients during Freeze-Drying Processing

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Gabriella Björkengren; [2021]
    Nyckelord :Biophysical chemistry; protein stability; molecular dynamics simulation; Chemistry;

    Sammanfattning : The purpose of this project was to investigate protein stabilization by formulation excipients during the process of freeze-drying using Molecular Dynamics (MD) simulation. A recombinant therapeutic protein, Reteplase, was used as a model and the study focused on a comparative analysis of two excipients, arginine and tranexamic acid (TXA), as included in commercially available formulations of Reteplase. LÄS MER

  3. 3. Ultrasonic Assisted Drying and its Effect on 3D Printability of Minced Beef and Other Foods

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Viktor Lindström; [2020]
    Nyckelord :Drying; Convection drying; Ultrasound; Ultrasonic drying; 3D-Printing; 3D-Printability; Food; Meat; Beef; Food technology; Livsmedelsteknologi; Technology and Engineering;

    Sammanfattning : The aim of this master thesis project was to investigate the impact on drying kinetics of ultrasound during air drying by a new ultrasonic transducer, on which a patent application has been filed by CSIRO. Convection drying using hot air is currently the conventional method of drying in the industry due to its simplicity and low cost. LÄS MER

  4. 4. Development of a Near Infrared Spectroscopy Model for Prediction of Fibre Compounds in Alfalfa

    Master-uppsats, Lunds universitet/Teknisk mikrobiologi

    Författare :Christina Andersen; [2020]
    Nyckelord :alfalfa; lucerne; medicago sativa; green protein powder; NIR; near infrared spectroscopy; model development; matlab; PLS; partial least squares; PCA; principal component analysis; SNV; standard normal variate; fibre prediction; TDF; total dietary fibre; applied microbiology; teknisk mikrobiologi; Technology and Engineering;

    Sammanfattning : Background: This project investigates if it is possible to develop a calibration model from near infrared (NIR) spectroscopic measurements, for determination of the amount and type of fibre fractions within protein powder produced from the legume alfalfa, without performing wet experiments. Alfalfa is also known as Medicago sativa and lucerne, but is in this project further referred to as alfalfa. LÄS MER

  5. 5. Freeze-drying of protein pharmaceuticalin vials with different character

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Julia Falk; [2019]
    Nyckelord :;

    Sammanfattning : Freeze-drying of protein pharmaceuticals is a procedure frequentlyused to obtain stability of the active pharmaceutical ingredientduring distribution and storage. It can be performed in pre-filledsyringes, with a lubricous coating of silicone on the inside, toenable the piston moving. LÄS MER