Sökning: "Freeze-drying"

Visar resultat 6 - 10 av 31 uppsatser innehållade ordet Freeze-drying.

  1. 6. Quality and Regulatory Issues Related to Continuous Manufacturing of Biologics

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Sorosh Ziarati; [2022]
    Nyckelord :Continuous Manufacturing; Regulation; Continuous freeze drying; Biopharmaceutical; Trastuzumab; Pharmaceutical Technology; Technology and Engineering;

    Sammanfattning : Introduction: Continuous Manufacturing involves the continuous feeding of input materials into the transformation of in-process materials within, and the concomitant removal of output materials from a manufacturing process based on ICH guideline. In these systems, all the processes from raw material to final finished product would be continuously produced. LÄS MER

  2. 7. Lipase in oat endosperm: The effect of freeze-drying and oven-drying

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Ilham Hassan; [2021]
    Nyckelord :Lipase; oat endosperm; whole grain oat flour; water activity.;

    Sammanfattning : The project was carried out in collaboration with Lantmännen with the aim to analyse the lipase activity in oat endosperm, non-heat-treated whole grain oat flour and heat-treated whole grain oat flour and to investigate whether lipase activity could be inactivated in oat endosperm by reducing water activity by various methods such as oven drying and freeze drying to extend oat shelf life. Lipase activity was measured by a wet extraction of the flour and an artificial substrate that gives a coloured product if lipase enzymes are active in the extract. LÄS MER

  3. 8. Determination of Mass- and Heat Transfer Coefficients for Computer Modelling of Pharmaceutical Freeze-Drying

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Linnea Gustafsson; [2021]
    Nyckelord :Freeze-drying; Mass- and Heat Transfer; Pharmaceutical production; Simulation; MATLAB; Pharmaceutical technology; Technology and Engineering;

    Sammanfattning : This thesis work deals with the determination of mass- and heat transfer coefficients for pharmaceutical vial freeze-drying and the one-dimensional steady state computer modelling of primary drying. The overall heat transfer coefficient K_V for the vial/freeze-dryer system was successfully determined using a gravimetric method. LÄS MER

  4. 9. Biobased carbon aerogels incorporated with zeolite nanoplates for carbon dioxide adsorption

    Uppsats för yrkesexamina på avancerad nivå, Luleå tekniska universitet/Institutionen för teknikvetenskap och matematik

    Författare :Maria Harila; [2021]
    Nyckelord :biobased; carbon aerogel; lignin; cellulose nanofiber; adsorption; carbon dioxide; zeolite nanoplate;

    Sammanfattning : Over the last 100 years there has been an increase of greenhouse gases (CO2, CH4 and N2O) in the atmosphere. These gases cause several problems with the climate on Earth, such as increasing problems with extreme weather. One way to decrease the outlet of carbon dioxide is by adsorption and capture of CO2. LÄS MER

  5. 10. A Molecular Dynamics Simulation Study of the Protein Stability of Reteplase in Formulation with Various Excipients during Freeze-Drying Processing

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Gabriella Björkengren; [2021]
    Nyckelord :Biophysical chemistry; protein stability; molecular dynamics simulation; Chemistry;

    Sammanfattning : The purpose of this project was to investigate protein stabilization by formulation excipients during the process of freeze-drying using Molecular Dynamics (MD) simulation. A recombinant therapeutic protein, Reteplase, was used as a model and the study focused on a comparative analysis of two excipients, arginine and tranexamic acid (TXA), as included in commercially available formulations of Reteplase. LÄS MER