Sökning: "Fusion gene"

Visar resultat 1 - 5 av 24 uppsatser innehållade orden Fusion gene.

  1. 1. Combining Cell Painting, Gene Expression and Structure-Activity Data for Mechanism of Action Prediction

    Master-uppsats, Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

    Författare :Erik Everett Palm; [2023]
    Nyckelord :bioinformatics; deep learning; machine learning; joint model; tabular data; image data;

    Sammanfattning : The rapid progress in high-throughput omics methods and high-resolution morphological profiling, coupled with the significant advances in machine learning (ML) and deep learning (DL), has opened new avenues for tackling the notoriously difficult problem of predicting the Mechanism of Action (MoA) for a drug of clinical interest. Understanding a drug's MoA can enrich our knowledge of its biological activity, shed light on potential side effects, and serve as a predictor of clinical success. LÄS MER

  3. 2. Toward prototyping metabolic pathways in cyanobacteria using cell extracts

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Amina Bensabra; [2022]
    Nyckelord :cyanobacteria; metabolic engineering; cell-free metabolic engineering; enzymes; sustainability; cyanobakterier; metabolisk genteknik; syntetisk biologi; enzymer; hållbar bioproduktion;

    Sammanfattning : Cyanobakterier är intressanta mikroorganismer för produktion av biobränslen från solljus, vatten och atmosfärisk koldioxid och anses därför vara potentiella mikrobiella cellfabriker. Men på grund av långsam tillväxt och låg produktion är genteknologi processen intensiv och tidskrävande för cyanobakterier. LÄS MER

  4. 3. Evaluation of strategies for construction of protease libraries in yeast.

    Master-uppsats, Lunds universitet/Teknisk mikrobiologi; Lunds universitet/Bioteknik

    Författare :Sidharth Jaya Sankar; [2022]
    Nyckelord :Yeast; GFP-fusion technology; protease; applied microbiology; Technology and Engineering;

    Sammanfattning : Proteases are a group of enzymes that are involved in breaking down larger proteins into smaller polypeptides or single amino acids, and they are used in various applications. In this project, the potential of budding yeast Saccharomyces cerevisiae as host for the construction of protease libraries is evaluated. LÄS MER

  5. 4. Genetically modified tobacco (Nicotiana tabacum) plants for an increased production of wax esters

    Kandidat-uppsats, SLU/Dept. Of Plant Biology

    Författare :Linn Nilsson; [2022]
    Nyckelord :Wax esters; metabolic engineering; nicotiana tabacum; fatty acid reductase; phytyl ester synthase;

    Sammanfattning : Wax esters (WE) are naturally occurring lipids consisting of a fatty acid bound to a fatty alcohol with an ester bond. As an alternative to petrochemicals, plant-derived WE:s are of considerable commercial interest as lubricants, but have in recent years also received great attention for their potential as a starting material for bio-fuel production. LÄS MER

  7. 5. Expression of the Sloppymerase™ in NIH/3T3 Cells: Exploring the Versatility of an Error Prone Fusion Polymerase

    Uppsats för yrkesexamina på grundnivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Mikaela Mattsson; [2021]
    Nyckelord :;

    Sammanfattning : The aim of this project is to assess the versatility of the Sloppymerase by performing stable transfection in NIH/3T3 cells and decide whether this cell line can be a candidate for further research on the Sloppymerase as a cancer model. The American cancer society predicts 1,806,590 new cancer cases in the US in 2020. LÄS MER