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Visar resultat 1 - 5 av 8 uppsatser som matchar ovanstående sökkriterier.
1. Inferring Gene regulatory networks using Graph Neural Networks
Master-uppsats, KTH/GenteknologiSammanfattning : Inom beräkningsbiologin är det snabbt på väg att bli allt vanligare att ta fram genetiska regleringsnätverk (GRN). På grund av storleken på de undersökta nätverken använder många forskare maskininlärning för att härleda GRN från genuttrycksdata, vanligtvis från RNA-seq. LÄS MER
2. Energy Landscapes for Early T Cell Development
Master-uppsats, Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationSammanfattning : T cell lineage development from an early thymic progenitor involves programmed shutoff of progenitor gene expression, upregulation of T cell specification genes, and proliferation. This biological system has been deeply studied and a gene regulatory network (GRN) that can accurately describe the system has been presented. LÄS MER
3. Imputing connections of random gene networks from time series data using ANNs
Master-uppsats, Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationSammanfattning : This thesis presents the architecture of a convolutional neural network which is trained to impute the connections of randomly generated gene regulatory networks under varying amounts of regularisation. The generated gene networks are simulated from 10 different starting conditions for each set of connections in order to obtain multiple time series. LÄS MER
4. A pipeline for the identification and examination of proteins implicated in frontotemporal dementia
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Frontotemporal dementia is a neurodegenerative disorder with high heterogeneity on the genetic, pathological and clinical level. The familial form of the disease is mainly caused by pathogenic variants of three genes: C9orf72, MAPT and GRN. LÄS MER
5. Patterning of the neural tube: A 3D computational modelling approach
Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisationSammanfattning : Neurodegenerative diseases such as Parkinson’s can be treated with stem-cell derived specialized neurons. In order to achieve precise directed neural differentiation in vitro we need to understand the gene regulatory mechanisms behind in vivo neural tube patterning. LÄS MER