Sökning: "Galectins"

Hittade 5 uppsatser innehållade ordet Galectins.

  1. 1. The Effect of Using DMSO as a Cosolvent for Ligand Binding Studies

    Master-uppsats, Lunds universitet/Biofysikalisk kemi

    Författare :Simon Birgersson; [2019]
    Nyckelord :Galectins; Nuclear Magnetic Resonance; NMR; Biophysical Chemistry; Relaxation; CPMG; ITC; Biofysikalisk Kemi; Kärnmagnetisk resonans; Technology and Engineering; Chemistry; Biology and Life Sciences;

    Sammanfattning : DMSO sees common application as a solvent for studies of synthetic molecules in biological systems, in fields such as drug design. Despite this, the possibility and nature of solvent interactions with both synthetic ligand and their target macromolecules is widely unexamined. LÄS MER

  2. 2. Investigation of α-thioaryl galactopyranosides to improve affinity towards Galectin-9N

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Sofi Gummesson; [2018]
    Nyckelord :organic chemistry; organisk kemi; Chemistry;

    Sammanfattning : Galectins are a family of carbohydrate recognition proteins involved in modulation of cell signaling and cell adhesion. galectin-9 especially is involved in regulation of the immune response. In this work, galectin-9N inhibitors have been designed, synthesized and evaluated. LÄS MER

  3. 3. Synthesis of fluorescent carbohydrate coumarin hybrids via a three-component reaction : nanomolar galectin-3 inhibitor

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Shaun Hoang; [2013]
    Nyckelord :Organisk kemi; Chemistry;

    Sammanfattning : Galectins play an important role in inflammation, immunity, cancer progression and are potential targets for novel anti-cancer and anti-inflammatory compounds. Coumarin thiodigalacoside hydrid had proved to be potent, nanomolar, and selective inhibitor of galectin-3. LÄS MER

  4. 4. Synthesis of 3-C-(4-aryl-5-halo-1,2,3-triazol-1-yl)-galactosides: Probing halogen bonding in galectin-ligand complexes

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Marcus Ljungberg; [2011]
    Nyckelord :Organisk kemi; Chemistry;

    Sammanfattning : The continued search for compounds exhibiting a better inhibition of Galectin-3 and -1 has been performed in this thesis. It has been shown that the Galectins are over-expressed in cancer cells and play an important role in inflammatory conditions connected to apoptosis (cell death). LÄS MER

  5. 5. An approach to diketone-galectin-3 inhibitor

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Shaun Hoang; [2011]
    Nyckelord :Organisk kemi; Chemistry;

    Sammanfattning : In many biological mechanisms galectins play important roles. The galectins are important in inflammation, immunologic response and cancer. A key function of galectins is cross-linking of their glycoprotein ligands which are connected with the biological activities. Carbohydrate recognition domains (CRD) are responsible for the cross-linking. LÄS MER