Sökning: "Gunnar Yngman"

Hittade 1 uppsats innehållade orden Gunnar Yngman.

  1. 1. Individualization of fixed-dose combination regimens : Methodology and application to pediatric tuberculosis

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Gunnar Yngman; [2015]
    Nyckelord :pharmacometrics; pharmacokinetics; PK; population pharmacokinetics; optimal design; FDC; fixed-dose combination; pediatrics; tuberculosis; rifampicin; pyrazinamide; isoniazid; ethambutol; modeling; simulation; estimation; allometric scaling; stochastical simulation and estimation; NONMEM; MATLAB; FO; FOCE; Expectation-Maximization algorithm; importance sampling; Nelder-Mead method; logistic function; discontinuity; euclidean distance; Sammon mapping; global minimum; local minima;

    Sammanfattning : Introduction: No Fixed-Dose Combination (FDC) formulations currently exist for pediatric tuberculosis (TB) treatment. Earlier work implemented, in the software NONMEM, a rational method for optimizing design and individualization of pediatric anti-TB FDC formulations based on patient body weight, but issues with parameter estimation, dosage strata heterogeneity and representative pharmacokinetics remained. LÄS MER