Sökning: "Gyros"

Visar resultat 1 - 5 av 17 uppsatser innehållade ordet Gyros.

  1. 1. Development and comparison of three immunoassay formats to screen for total anti-adeno-associated virus serotype 2 antibodies in human serum using the Gyrolab immunoassay platform

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Elin Eriksson; [2020]
    Nyckelord :Adeno-associated virus; AAV; anti-AAV; TAb; Gyrolab; immunity; immunoassay;

    Sammanfattning : Recombinant adeno-associated virus vectors are one of the most promising gene delivery tools for applications within gene- and cell therapy. The high level of wild-type adeno-associated virus infections in humans is a limitation due to the pre-existing immunity against the vector or its transgene product. LÄS MER

  3. 2. Evaluating Response Images From Protein Quantification

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Mathias Engström; Erik Olby; [2020]
    Nyckelord :Deep Learning; Protein Quantification; Gyros; Gyrolab; Automation; Image Processing; Simulation; CNN; DCNN; Image Simulation; Artefact Detection; Image Quality; Machine Learning; Image Classification;

    Sammanfattning : Gyros Protein Technologies develops instruments for automated immunoassays. Fluorescent antibodies are added to samples and excited with a laser. This results in a 16-bit image where the intensity is correlated to concentration of bound antibody. LÄS MER

  4. 3. Artefact detection in microstructures using image analysis

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Oskar Stenerlöw; [2020]
    Nyckelord :;

    Sammanfattning : Gyros Protein Technologies AB produce instruments designed to perform automated immunoassaying on plastic CDs with microstructures. While generally being a very robust process, the company had noticed that some runs on the instruments encountered problems. They hypothesised it had to do with the chamber on the CD in which the sample is added to. LÄS MER

  5. 4. Development of a method for kinetic characterisation of therapeutic antibodies in solution using the Gyrolab platform

    Uppsats för yrkesexamina på avancerad nivå,

    Författare :Josef Pelcman; [2019]
    Nyckelord :kinetics; affinity; gyros; antibodies; antibody; kinetic; association; dissociation; affinity chromatography;

    Sammanfattning : Therapeutic antibodies dominate the pharmaceutical market and improve the lives of millions of people annually. One important step when developing new medicines is to kinetically characterise the drug candidates. For antibodies this is difficult since many antibody reactions are extremely slow. LÄS MER

  7. 5. Optimization of a pharmacokinetic assay in a bridging assay format using the Gyrolab immunoassay platform

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Biokemi

    Författare :Ebba Spetsare; [2019]
    Nyckelord :bridging assay; gyros; affinity; humira; tnf-alfa; pharmacokinetic;

    Sammanfattning : Anti-TNF alpha antibodies were among the first approved antibody drugs and now belongs to the best-selling drugs. Today, several companies are developing biosimilars to those drugs which will increase the access of medications and potentially reduce health care costs. LÄS MER