Sökning: "HER2"

Visar resultat 1 - 5 av 29 uppsatser innehållade ordet HER2.

  1. 1. Vilka läkemedelsframsteg har förbättrat prognosen för HER2-positiv metastaserad bröstcancer? : En litteraturstudie

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Helena Hansson; [2023]
    Nyckelord :HER2; Bröstcancer; Läkemedel;

    Sammanfattning : Breast cancer is one of the deadliest forms of cancers in the world. About 15–30% of all breast cancers are HER2-positive, which involves overexpression of HER2-receptors on the surface of tumor cells. LÄS MER

  3. 2. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

    Författare :Astrid Haraldsson; [2023]
    Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

    Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

  4. 3. Using Generative Adversarial Networks for H&E-to-HER2 Stain Translation in Digital Pathology Images

    Master-uppsats, Linköpings universitet/Institutionen för medicinsk teknik

    Författare :William Tirmén; [2023]
    Nyckelord :Machine learning; Artificial intelligence; Digital pathology; Image processing; Generative adversarial networks; Image-to-image translation;

    Sammanfattning : In digital pathology, hematoxylin & eosin (H&E) is a routine stain which is performed on most clinical cases and it often provides clinicians with sufficient information for diagnosis. However, when making decisions on how to guide breast cancer treatment, immunohistochemical staining of human epidermal growth factor 2 (HER2 staining) is also needed. LÄS MER

  5. 4. Automated HER2 Scoring of Breast Cancer Tissue using Upconverting Nanoparticle Images

    Master-uppsats, Lunds universitet/Matematik LTH

    Författare :Adam Belfrage; Alexander Wik; [2022]
    Nyckelord :HER2-scoring; image analysis; interpretability; digital pathology; computer aided pathology; whole slide imaging; ASCO-guidelines; singular value decomposition; shape models; Bayesian classification; Biology and Life Sciences; Medicine and Health Sciences; Technology and Engineering; Mathematics and Statistics;

    Sammanfattning : Computer aided pathology is becoming more and more of a requirement within pathology due to increased demand of individualised treatments and personalised medicine. Because of the advance of digital pathology in recent years, where a high resolution camera acquire images of microscope slides, pathologists can now assess tissue samples in digital images. LÄS MER

  7. 5. The density of CD163+ macrophages in different subtypes of breast cancer

    Master-uppsats, Örebro universitet/Institutionen för medicinska vetenskaper

    Författare :Julia Andersson; [2022]
    Nyckelord :breast cancer; molecular subtypes; macrophages; immunohistochemistry; CD163;

    Sammanfattning : Introduction Breast cancer is the most common cancer among women in Sweden and world-wide. Immunohistochemical (IHC) expression of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 is routinely performed for diagnostic and prognostic purposes. LÄS MER