Sökning: "HepG2"

Visar resultat 1 - 5 av 11 uppsatser innehållade ordet HepG2.

  1. 1. Development of Microfluidic 3D Cell Culture with a Nanocellulose-Based Scaffold for Spheroid Formation as a Potential Tool for Drug Screening

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Sara Payande; [2022]
    Nyckelord :3D cell culture; Scaffold; Microfluidics; Layer-by-Layer; Cellulose Nanofibrils; Spheroids; HepG2; 3D cellodling; Matris; Mikrofluidik; Layer-by-Layer; Cellulosa Nanofibriller; Sfäroider; HepG2;

    Sammanfattning : Abstract  Lack of clinical relevance is assumed to be the main reason behind the high failure rate of medical drugs in the very initial phases of clinical trials. Clinical relevance is difficult to achieve with current tools as they lack the biological and physiological cues found in vivo. LÄS MER

  3. 2. Predicting Mechanisms of Toxicity for Drug Development

    Master-uppsats, Göteborgs universitet/Institutionen för data- och informationsteknik

    Författare :SÖREN RICHARD STAHLSCHMIDT; [2019-10-04]
    Nyckelord :Predictive Toxicology; Metabolomics; Semi-Supervised Learning; DoseResponse;

    Sammanfattning : The aim of this thesis is to predict different mechanisms of toxicity from the metabolomic response of HepG2 liver cells. In order to utilize the metabolomic data the a semisupervised machine learning approach is investigated, namely the cluster-then-label approach. LÄS MER

  4. 3. Analysis of hydrogels for immobilisation of hepatocytes (HepG2) in 3D cell culturing systems

    Master-uppsats, Linköpings universitet/Teknisk biologi

    Författare :Elisabeth Westergren; [2018]
    Nyckelord :Hydrogel; Hepatocyte; Tuneable; PEG-peptide; 3D cell culture;

    Sammanfattning : In pharmaceutical development cell cultures are used as in vitro models to evaluate the function of drug candidates. In such research it is vital to have models that resemble the in vivo environment to get reliable results. LÄS MER

  5. 4. Development of a combined In-Cell ELISA and flow cytometry method for quantification of uptake of PEGylated nanoparticles by Raw264.7 and HepG2 cells

    Master-uppsats, Lunds universitet/Tillämpad biokemi

    Författare :Evelina Folkesson; [2016]
    Nyckelord :HepG2; Raw264.7; PEGylation; PEG; cancer; nanoparticles; In-Cell ELISA; flow cytometry; applied biochemistry; tillämpad biokemi; Technology and Engineering;

    Sammanfattning : Cancer is one of today’s most common causes of human mortality. For long, chemotherapeutics has been a conventional treatment of the disease, but due to its low precision and high frequency of side effects, this treatment has been highly debated. LÄS MER

  7. 5. In Vitro Studies on the Uptake of Ion-X-Gel Precursor and SPIO by Various Cell Types

    Master-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

    Författare :Hampus Lundqvist; [2014]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Abstract Contrast agents for MRI can greatly improve the contrast in the image, making it easier to pinpoint the position of, for example, inflamed tissues or tumors. There is a need for novel contrast agents with better spatial resolution, higher sensitivity, fewer false positives and lower toxicity. LÄS MER