Sökning: "Herpes Simplex Virus 1"

Hittade 5 uppsatser innehållade orden Herpes Simplex Virus 1.

1. 1. Epidemiologiska modeller för herpesvirusets roll i kognitiv svikt

   Master-uppsats, Uppsala universitet/Folkhälsovetenskap

   Författare :Peter Lyttkens; [2021]
   Nyckelord :apolipoprotein e4; cognitive impairment; hsv1; MMSE; precision public health; apolipoprotein e4; kognitiv nedsättning; hsv1; MMSE; precision public health;

   Sammanfattning : Introduction: Cognitive impairment is converted for 15% to Alzheimer’s disease (AD), which is incurable. The aim of this study is to investigate whether Herpes simplex virus type 1 (HSV1) and its interaction with allele ε4 of Apolipoprotein E (ApoE-ε4) may be possible risk factors for cognitive impairment. LÄS MER

3. 2. Exploration of Zinc finger CCCH domain-containing protein 11A’s role in mammalian cell NFkB Pathway

   Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

   Författare :Jianxiang Wang; [2019]
   Nyckelord :ZC3H11A; NFkB; HeLa cells; Viral-host interaction;

   Sammanfattning : ZC3H11A (ZC3) protein has been reported to be part of the TREX (TRanscription-EXport) nuclear export system for mammalian cells. According to our previous publication, ZC3 not only plays an unelucidated role in the TREX complex, but also supports the growth of several human nucleus replicating virus, such as influenza virus, adenovirus (HAdV), herpes simplex virus and HIV. LÄS MER

4. 3. Jämförelse av kommersiella och InHouse kontroller för realtids-PCR vid diagnostik av Herpes simplexvirus 1 och 2

   Kandidat-uppsats, Högskolan i Jönköping/HHJ, Avd. för naturvetenskap och biomedicin

   Författare :Samuel Karlsson; Nelly Palma Jansson; [2018]
   Nyckelord :DNA; storage; stability; DNA; förvaring; stabilitet;

   Sammanfattning : Herpes simplexvirus 1 och 2 orsakar godartade sjukdomar, men kan även orsaka mortalitet. Diagnostik av herpes simplexvirus 1 och 2 utförs numera framför allt med realtids- Polymerase chain reaction (PCR). I metoden amplifieras specifika deoxiribonukleinsyra(DNA)-sekvenser till miljontals kopior vilka sedan detekteras med fluorescein. LÄS MER

5. 4. Effects of herpes simplex virus 1 (HSV-1) infection on nuclear amyloid aggregation

   Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Författare :Maria Arone Blanco; [2018]
   Nyckelord :Huntington’s disease; Spinocerebellar ataxia; Amyloids; Protein aggregation; Herpes Simplex Virus 1; HSV-1; Virus infection; oligonucleotides; Filter retardation Assay; Dot Blot.; Huntingtons sjukdom; Spinocerebellära ataxier; Amyloider; Protein aggregering; Herpes Simplex Virus 1; HSV-1; Virus infektion; Oligonukleotider; Filter retardation Assay; Dot Blot.;

   Sammanfattning : Huntington’s disease (HD) and Spinocerebellar ataxia (SCA) are incurable neurodegenerative diseases that affect the central nervous system. Amyloids, highly organized protein aggregates, are a hallmark for many neurodegenerative diseases. The presence and accumulation of amyloids are toxic and constitute the major cause of neuron cell death. LÄS MER

7. 5. Cloning, Expression and Purification of a Mutant Tomato Thymidine Kinase 1 for Crystallography

   Master-uppsats, Lunds universitet/Tillämpad biokemi

   Författare :Mohamad Nesrini; [2015]
   Nyckelord :protein expression; protein engineering; Azidothymidine; thymidine kinase; deoxyribonucleoside kinases; nucleosides; nucleoside analog; suicide gene therapy; tillämpad biokemi; applied biochemistry; BEVS.; Technology and Engineering; Chemistry;

   Sammanfattning : Thymidine kinase 1 from tomato (ToTK1) is a newly discovered deoxyribonucleoside kinase (dNK) that has been subject to study due to its in vitro and in vivo properties making it an interesting suicide gene candidate for the treatment of brain tumors. The ToTK1 phosphorylates the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (dThd). LÄS MER