Sökning: "High resolution mass spectrometry"

Visar resultat 1 - 5 av 19 uppsatser innehållade orden High resolution mass spectrometry.

  1. 1. Synthesis of aromatic thiol ligands for the formation of thermoelectric materials

    Master-uppsats, KTH/Kemi

    Författare :Clément Bouchut; [2024]
    Nyckelord :ligand; organic chemistry; organic synthesis; thermoelectric materials; thiol; ligand; organisk kemi; organisk syntes; termoelektriska material; tiol;

    Sammanfattning : I detta arbete så har en uppsättning aromatiska ditiol-ligander framställts (3,5-dimerkaptobensoesyra I, methyl-3,5-dimerkaptobensoat II, 3,5-dimerkaptotoluen III, 4,6-dimerkaptoisoftalaldehyde IV). En trestegssyntes innehållande Newman-Kwart omlagring som nyckelsteg användes för framställning av föreningarna I-III medan förening IV togs fram via en annan syntesväg. LÄS MER

  3. 2. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  4. 3. Identification of photodegradation products from commonenvironmental pollutants using gas chromatography coupled withhigh resolution mass spectrometry

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Vanessa Cajes; [2022]
    Nyckelord :Photodegradation; Organic contaminants; High resolution mass spectrometry; Identification; Spectral library;

    Sammanfattning : Photodegradation is a major degradation mechanism for many environmental contaminants, both in indoor environments as well as in outdoor environments, and many of the contaminants are persistent and toxic. However, there is a lack of knowledge about the exact degradation process for many of them. LÄS MER

  5. 4. The effects of urine adulteration with oxidants before drug analysis with LC-HRMS and CEDIA

    Kandidat-uppsats, Uppsala universitet/Institutionen för medicinsk cellbiologi

    Författare :Anna Nilsson; [2022]
    Nyckelord :Drugs of abuse; Manipulation; Mass spectrometry; Narcotics; Tampering;

    Sammanfattning : In drug analysis, different kinds of immunoassays are often used as an initial screening for urine samples. The positive screening results are then followed by a confirmatory test, which consists of mass spectrometry methods to detect the drugs. The confirmatory tests are considered to be more resistant to manipulation than the screening tests. LÄS MER

  7. 5. Building an in-house spectral library using GCorbitrap HRMS

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Elias Kolsmyr; [2022]
    Nyckelord :Environmental contaminants; Plastic additives; Gas chromatography; High resolution mass spectrometry; Spectral library; MS-DIAL;

    Sammanfattning : There are a great variety of environmentals contaminants, a lot of which are understudied asit is today. The aim of this study was to develop an in-house high-resolution spectral librarycontaining environmental contaminants, with focus on plastic additives. The spectral librarywould then be used to perform suspect screening on real sample extracts. LÄS MER