Sökning: "Ismini - Christina Stamatelou"

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  1. 1. Clustering approaches for extracting structural determinants of enzyme active sites

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Ismini - Christina Stamatelou; [2020]
    Nyckelord :Structural bioinformatics; enzyme; active site; glycogen phosphorylase; clustering; rotamer; conformation; k-means; clara;

    Sammanfattning : The study of enzyme binding sites is an essential but rather demanding process of increased complexity since the amino acids lining these areas are not rigid. At the same time, the minimization of side effects and the specificity of new ligands is a great challenge in the structure-based drug design approach. LÄS MER