Sökning: "Massivt Parallellt Bibliotek"

Hittade 1 uppsats innehållade orden Massivt Parallellt Bibliotek.

  1. 1. Modeling the intronic regulation of Alternative Splicing using Deep Convolutional Neural Nets

    Master-uppsats, KTH/Skolan för datavetenskap och kommunikation (CSC)

    Författare :Johannes Linder; [2015]
    Nyckelord :Machine Learning; Deep Learning; CNN; CNNs; Convolutional Neural Networks; Convolutional Neural Nets; Neural Networks; Neural Nets; Synthetic Biology; Alternative Splicing; AS; Splicing; DNA Regulation; Synthetic DNA; Massively Parallel Library; Maskinlärning; CNN; CNNs; Convolutional Neural Networks; Convolutional Neural Nets; Faltning; Neurala Nätverk; Neurala Nät; Syntetisk Biologi; Alternativ Splicing; Splicing; AS; DNA; Massivt Parallellt Bibliotek; Syntetiskt DNA;

    Sammanfattning : This paper investigates the use of deep Convolutional Neural Networks for modeling the intronic regulation of Alternative Splicing on the basis of DNA sequence. By training the CNN on massively parallel synthetic DNA libraries of Alternative 5'-splicing and Alternatively Skipped exon events, the model is capable of predicting the relative abundance of alternatively spliced mRNA isoforms on held-out library data to a very high accuracy (R2 = 0. LÄS MER