Sökning: "Medicinal chemistry"

Visar resultat 1 - 5 av 13 uppsatser innehållade orden Medicinal chemistry.

  1. 1. A novel approach for functionalising and separating Tröger's Base Analogues

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Emil Jakobsson; [2023]
    Nyckelord :Tröger s Base; Synthesis; Chromatography; Supramolecular chemistry; Diastereomers; Organic chemistry; Chemistry;

    Sammanfattning : Tröger’s Base (TB) is a bicyclic compound containing a methanodiazocine group between two aromatic rings. The methylene bridge forces the molecule to have a bent formation; thus, the aromatic rings are close to 90 degrees relative to each other, resulting in a rigid concave aromatic cavity. LÄS MER

  3. 2. Exploring a unique pocket in Galectin-8N by the synthesis of D-galactoside-based benzimidazole inhibitors

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Sid Bartold; [2023]
    Nyckelord :organic chemistry; synthesis; gal; gal-8; gal-8N; galectin; galectin-8; galectin-8N; inhibitor; drug development; benzimidazole; galactoside; carbohydrate; carbohydrate chemistry; Suzuki-coupling; Chemistry;

    Sammanfattning : Galectins are a family of glycan-binding proteins where galectin-8 is a part of the subgroup known as tandem-repeat type galectins. Galectin-8 is composed of two homologous CRDs, one N- and one C-terminal CRD. As it stands now, galectin-8N has been found to bind to a larger number of glycans than galectin-8C. LÄS MER

  4. 3. The Synthesis and Development of Potential Small Molecule Splice Modifiers toward a central nervous system (CNS) target for the treatment of a genetic disease

    Master-uppsats, KTH/Kemiteknik

    Författare :Flore Miomandre; [2023]
    Nyckelord :organic synthesis; medicinal chemistry; pharmaceutical candidate; small molecule; genetic disease; organisk syntes; läkemedelskemi; läkemedelskandidat; småmolekylär; genetisk sjukdom;

    Sammanfattning : Behandling av sällsynta sjukdomar är en stående utmaning inom läkemedelskemi då mer än 400 miljoner människor lider av 7000 olika sällsynta sjukdomar där få godkända läkemedel finns tillgängliga. Fokus för detta arbete är att syntetisera läkemedelskandidater för en sällsynt och livslång form av epilepsi med frekventa och långvariga anfall. LÄS MER

  5. 4. Development of a Graphical User Interface For Easier Overview of Historical Chromatography Data

    Master-uppsats, Lunds universitet/Kemiteknik (CI)

    Författare :Agnes Hermansson; [2021]
    Nyckelord :GUI; graphical user interface; PyQt5; Orbit; Chromatography; data visualization; chemical engineering; Chemistry;

    Sammanfattning : Chromatography is a separation technique frequently used in the purication of medicinal drugs. In studies and project at the department of chemical engineering at Lund University a large amount of data have been generated through the use of their research software Orbit and their ÄKTA chromatography system. LÄS MER

  7. 5. A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Madeleine Andersson; [2020]
    Nyckelord :Pharmaceutical technology; Läkemedelsteknologi; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : A great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. LÄS MER