Sökning: "Mitogen-activated protein kinase kinase kinase"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden Mitogen-activated protein kinase kinase kinase.

  1. 1. Utsöndrade extracellulära vesiklar (EV) från hästens spolmask Parascaris univalens och deras immunmodulerande roll

    Uppsats för yrkesexamina på avancerad nivå, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Karin Tufvesson; [2022]
    Nyckelord :Extracellulära vesiklar; Parascaris univalens; hästens spolmask; ST2; DUSP1; PCR;

    Sammanfattning : Under det senaste decenniet har ett nytt forskningsområde vuxit fram som handlar om kartläggning av extracellulära vesiklar (EV) från parasiter samt hur de kan påverka värddjurets immunförsvar. EV är lipidmembranförsedda blåsor innehållande bland annat proteiner och nukleinsyror och som används för cellkommunikation. LÄS MER

  3. 2. Towards Identifying Pharmacodynamic Blood Biomarkers of MAP3K12 Inhibition

    Master-uppsats, Lunds universitet/Tillämpad biokemi

    Författare :Elisabeth Jirström; [2017]
    Nyckelord :Mitogen-activated protein kinase kinase kinase; MAP3K12; Amyotrophic lateral sclerosis; DLK; ALS; Pharmacodynamic; Biomarker; applied biochemistry; tillämpad biokemi; Technology and Engineering; Biology and Life Sciences; Medicine and Health Sciences; Chemistry;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons in the brain and spinal cord, for which there is no cure. Activation of the stress-induced c-Jun N-terminal kinase (JNK) signaling pathway, a critical mediator of neuronal apoptosis and axon degeneration, is evident in ALS and is therefore considered a potential target to prevent neurodegeneration. LÄS MER

  4. 3. Characterization of pERK expression in amygdala and its role in nociceptive behavior

    Kandidat-uppsats, SLU/Dept. of Microbiology

    Författare :Mychelly Moraes De Siqueira; [2016]
    Nyckelord :amygdala; extracellular signal-regulated kinase ERK ; mitogen-activated protein kinase MAPK ; nociceptive; pain;

    Sammanfattning : Extracellular signal-regulated kinase (ERK), is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases. Functioning as intracellular signaling molecules, they are responsible for multiple extracellular signals transduction into diverse intracellular responses through transcriptional and post-translational regulations. LÄS MER

  5. 4. Role of MKP-2 in crosstalk between MAPK pathways

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Ludwiginstitutet för cancerforskning

    Författare :Mikaela Åhlin; [2015]
    Nyckelord :;

    Sammanfattning : Abnormalities in Mitogen Activated Protein Kinase (MAPK) signalling may affect the cells essential processes and influence the cell in acquiring traits to favour tumorigenic transformation and the progression of cancer. Deregulation of the MAPK pathways and uncontrolled crosstalk occurring in cancers may be caused by deregulation by MAP-kinase phosphatases (MKPs) that negatively regulates MAPKs by dephosphorylation. LÄS MER

  7. 5. Heme degradation pathway controls inflammation in model of mouse prostatitis

    Master-uppsats, Lunds universitet/Examensarbeten i molekylärbiologi

    Författare :Lisa Vikström; [2015]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Acute or chronic inflammation in the prostate is implicated in pathogenesis of benign prostate hyperplasia (BPH) as well as development of prostatic intraepithelial neoplasia (PIN) and prostate cancer (PCa). Chronic prostatitis (inflammation in the prostate) is associated with high morbidity and negatively impacts life quality. LÄS MER