Sökning: "Moira Ek"

Hittade 1 uppsats innehållade orden Moira Ek.

  1. 1. Bacterial Display of a Tau-Binding Affibody Construct:Towards Affinity Maturation

    Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Författare :Moira Ek; [2020]
    Nyckelord :Microtubule-associated protein tau; Neurodegenerative disorders; Alzheimer’s disease; Affibody molecules; Affinity maturation; Staphylococcal surface display; Escherichia coli display; Flow cytometry; Cell sorting;

    Sammanfattning : Aggregation of microtubule-associated protein tau is involved in the pathology of several neurodegenerative diseases, including Alzheimer’s disease. The affibody TP4 has been shown to inhibit this aggregation process, and its target-binding positions were previously grafted onto a dimeric affibody scaffold, creating the sequestrin seqTP4. LÄS MER